The newborn infant produces two to three times higher bilirubin than do adults. This is due to increased numbers of red blood cells innewbornsthat also have a shorter life span. • There is a decreased bilirubin clearance mainly due to the deficiency of the enzyme uridine diphosphogluconurate...
Total and indirect bilirubin levels were not significantly associated with T2D in either cohort. In conclusion, our findings do not support the protective association between serum bilirubin levels and incident T2D in the middle-aged and elderly adults; instead, direct bilirubin levels were associated ...
a, Percentage of infant gut metagenomes missingbilRduring their first year of life. The period of highest jaundice susceptibility is indicated by a shaded blue area on the plot.b, Comparison ofbilRabsence in samples from healthy adults and infants in their first month of life.c, Comparison o...
P—postnatal age in days; Ad—adults, more than 6-month-old; jj—hyperbilirubinemic Gunn rats; Ctrls—normobilirubinemic age-matched Gunn rats; f-Ctx—frontal cortex; h-Ctx—parietal cortex; IC—Inferior colliculi; Hip—hippocampus; PCs—pyramidal cells; DG—Dentate gyrus; CA—Cornus of ...
While this process is slow in adults, the blood–brain barrier of neonates is particularly permeable to bilirubin in the first days of life, and hyperbilirubinemia contributes to vascular dysfunction that causes additional susceptibility to bilirubin-induced neurotoxicity [32]. Once bilirubin enters the...