The normal concentration of bilirubin in the blood of a healthy person lies in the range of 0.3–1.9 mg dL−1 that covers conjugated bilirubin (0.1– 0.4 mg dL−1), unconjugated bilirubin (0.2– 0.7 mg dL−1) and a minor amount of non–protein-bound unconjugated...
(Knudsen, 1990). The termphysiologic jaundicerefers to the common, transient, indirect (unconjugated) hyperbilirubinemia in normalnewborns. However, jaundice should be considered abnormal if it is present in the first 36 hours of life, persists beyond 10 days of life, is greater than 12 mg/dL,...
Normal findings Adult/elderly/child [2] : Total bilirubin: 0.3-1.0 mg/dL or 5.1-17 μmol/L (SI units) Indirect bilirubin: 0.2-0.8 mg/dL or 3.4-12.0 μmol/L (SI units) Direct bilirubin: 0.1-0.3 mg/dL or 1.7-5.1 μmol/L (SI units) Newborn [2] : Total bilirubin: 1.0-12....
indirect bilirubin and incident CHD.The potential protective effect of total bilirubin within the normal range on incident CHD should be mainly attributed to mild-to moderate elevated levels of indirect bilirubin.Keywords: Bilirubin, cohort study, incident coronary heart diseaseAdditional informationFun...
The value found (11.4 ± 0.2 nM) was in the range of reported values of free serum bilirubin (8.5–13.1 nM)1. In such a range, the observed system is the most adaptable to changes (highest slope). This finding means that small changes in the extracellular bilirubin ...
Elevated plasma bilirubin levels are a frequent clinical finding. It can be secondary to alterations in any stage of its metabolism: (a) excess bilirubin production (i.e., pathologic hemolysis); (b) impaired liver uptake, with elevation of indirect bilir
When TBil is in normal range, higher DBil may indicate hepatocellular injury29. Several studies had reported that DBil had more significant relationship to metabolic syndrome21,30 and stroke31 than TBil and IBil. Therefore, it is important to distinguish the temporal associations between different ...
It was not until the 1980s that researchers discovered that the story was not so simple: bilirubin was toxic at high doses, but within the normal physiologic range this molecule serves as the most powerful antioxidant in the serum [5]. In fact, an enzyme preserved throughout all eukaryotic...
In human body fluids such as bile and serum, bilirubin exists in several different forms, these forms commonly being referred to in the art as conjugated bilirubin (Bc, both mono- and diconjugated forms), unconjugated bilirubin (Bu, also known as indirect bilirubin), and delta bilirubin (also...
In addition, although cognitive function in affected children was shown to be within the normal range in children with kernicterus [3], alterations were found in other studies [11]. Indeed, lasting consequences of neonatal hyperbilirubinemia in term infants were observed at age 30 years. Cognitive...