When the concentration of free bilirubin diacid exceeds its limit of aqueous solubility (≈70 nM at physiological pH), the compound exists as solubleoligomersand metastablemicroaggregates. Moreover, at very high concentrations of the diacid, insoluble precipitates form and may result in majorinjuryto...
Neonates are at risk for hyperbilirubinemia, because (1) they produce increased amounts of bilirubin at birth; (2) they have low expression of glucuronosyl transferases, the enzymes responsible for glucuronide conjugation; and (3) they have high rates of red blood cell turnover. Kernicterus is...
;\thigh molar ratios of biliru- bin :albumin and in the presence of high amino acid concentra- tions . displacement of bilirubin uccurs , hut the mai:nitudc: of displacement is small. Thus, the administration of J)arentcral solutions containing amino acids to sick infants with unconju- ...
The presence of the bulky endo- n-butyl groups and the high lipophilicity of the compound seemed to interfere with glucuronidation in the liver only slightly. In contrast, the similar, yet even more lipophilic n-butyl rubin 1, which has two exo n-butyl groups, was glucuronidated and ...
They fulfil not only low-cost and small size requirements, but they also provide practical advantages, such as low detection limit, high flexibility, fast response time, high reproducibility [28–30], and have also great potential for miniaturization and mass production. Hence, in the present ...