Bilirubinis the terminal metabolite of heme catabolism, is metabolized solely by UDP-glucuronosyltransferase (UGT) 1A1 through glucuronidation (Bosma et al., 1994), and accumulates in newborns because of a developmental delay in the expression of the UGTs (Burchell et al., 1989). Convincing evi...
Bilirubin levels alone are not specific enough to predict bilirubin toxicity or encephalopathy because in ill infants kernicterus can occur in the context of low serum bilirubin concentrations. Measurements of serum bilirubin are commonly – but not universally – performed in newborns. One study found...
The pivotal role that “free” bilirubin played in the bilirubin toxicity that occurred following administration of sulfisoxazole or benzyl alcohol to jaundiced newborns, and the correlation of “free” bilirubin with bilirubin-induced changes in the auditory brainstem response are strong support for ...
There were extremely significant differences between preterm and full-term newborns in terms of platelet count, C-reactive protein, total serum bilirubin, and transcutaneous bilirubin level. Levels of total serum bilirubin and transcutaneous bilirubin were stratified from 2nd to 5th day of m...
Time-limited phototherapy of term newborns in ABO hemolytic disease and hyperbilirubinaemiaPeer Revieweddoi:10.1515/jpme.1975.3.3.198Rosta, J.Makói, Z.Békefi, D.Várady, E.Walter de Gruyter, Berlin / New YorkJournal of Perinatal ... J Rosta,Z Makói,D Békefi,... - 《Journal of Perin...
Is hyperbilirubinaemia in appendicitis a better predictor of perforation than C-reactive protein? - a prospective study. To compare the performance for the prediction of perforated appendicitis of total bilirubin versus C-reactive protein (CRP), white blood cell count, the ti... MA Beltran,PE Me...
Because of inflammation of the liver cells or lack of an enzyme in the liver cells or the low viability of the enzyme, it can not excrete bilirubin very well, Such as neonatal hepatitis or sepsis. Newborns born within a week of physiological jaundice, it is because of low liver enzyme ...
Early change in bilirubin level GAHS: Glasgow alcoholic hepatitis score HCl: Hydrochloric acid HELLP: Hemolysis, elevated liver enzyme levels, and low platelet count HIV: Human immunodeficiency virus HMOX: Heme oxygenase HPLC: High-performance liquid chromatography ...
In this study the effect of conventional phototherapy on platelet count was studied in 101 newborns with indirect hyperbilirubinemia, out of whom 50 patients (49.5%) had decreased levels of platelets; 20 (19.8%) of the latter had a platelet count of below 100000/mm3. Decreased platelet count ...
particularly in premature babies. This is because the blood-brain barrier is not fully developed in newborns/premature babies, and therefore the lipid-soluble (i.e., water-insoluble) unconjugated bilirubin gets to the brain and is deposited in the lipid-rich basal ganglia and other regions, th...