Define Bile acid sequestrant. Bile acid sequestrant synonyms, Bile acid sequestrant pronunciation, Bile acid sequestrant translation, English dictionary definition of Bile acid sequestrant. n. A chemical that promotes sequestration. American Heritage®
preferred method, the bile acid sequestrant of the present invention is made by free radical-initiated precipitation polymerization of a mixture of ethylenically unsaturated monomers from an aqueous phase. Preferably, to reduce swelling of the precipitating polymer, the aqueous phase is a salt ...
The sequestrant is a substance used to cure bile salt diarrhea. They bind to bile salts by hydrophobic and electrostatic forces to stop them from contact with colon mucosa. The block copolymer could be used as bile salt binding agents. Herein, the physicochemical parameters between bile salt ...
The diarrhea in this situation usually reacts to bile salt sequestrants.163 Also, a few cases of pancreatitis have been reported in patients who have this disease.164 Interestingly, liver steatosis (sometimes with progression to steatohepatitis) may develop in the liver graft.158,165 Benign ...
The conjugated BA could be transported by bile salt export protein (BSEP) and multidrug resistance associ- ated protein 2 (MRP2) from the hepatocytes into the canaliculi, and subsequently the gallbladder to form the bile. After feeding or food intake, the presence of nutri- ents (especially ...
diarrhea leads to water and essential salt loss with the consequent risk of dehydration and the normal treatment of hydration and administration of essential salts sometimes is ineffective. Oral administration of cholestyramine has also been beneficial in instances where diarrhea is considered to be ...
The excess bile acids in the colon cause diarrhea, and treatment with bile acid sequestrants is beneficial. The condition can be diagnosed with difficulty by measuring fecal bile acids, or more easily by retention of selenohomocholyltaurine (SeHCAT), where this is available. Chronic diarrhea ...
BAM has been described in a subgroup of patients with diarrhea-predominant IBS (IBS-D) and bile acid sequestrant therapy has produced symptomatic improvement in diarrhea.76,77Given the location of the ileal bile salt transporter in the distal ileum, patients with CD are predisposed to BAM as ...
Hofmann, A. F. (1963(b)). The function of bile salts in fat absorption. The solvent properties of dilute micellar solutions of conjugated bile salt.Biochem. J.,89, 57 PubMedCASGoogle Scholar Hofmann, A. F. (1965). Clinical implications of physicochemical studies on bile salts.Gastroenterolo...
This is clinically manifest as diarrhea and generally responds to administration of a bile acid sequestrant. Ileal Resection Resection of the terminal ileum causes bile acid malabsorption. If the resection is small, the effect on bile acid metabolism is minimal. Increased biosynthesis occurs to ...