The liver takes up bile salts from blood to generate bile, enabling absorption of lipophilic nutrients and excretion of metabolites and drugs1. Human Na+–taurocholate co-transporting polypeptide (NTCP) is the main bile salt uptake system in liver. NTCP is also the cellular entry receptor of hum...
The line of investigations which have led to the physicochemical characterization of the complex bile salt/lecithin/cholesterol in bile, is reminded. The near saturation level of cholesterol, in normal human bile, is a probable factor in the frequent build-up of cholesterol gallstones. Studies on...
TACA was also found to inhibit ATP-mediated transport of TCA in rat Bsep (bile salt export protein)-containing plasma membrane vesicles of Sf9 insect cells but was not itself transported by any ATP-dependent mechanisms in this system, suggesting that it is not transported by the rat Bsep ...
On a functional level, bile salt uptake across the basolateral (fetal facing) membrane is Na+-independent and thus could be Oatp/OATP-mediated [19]. Furthermore, during pregnancy the placenta is a major source of steroid hormones that are transported as sulfate conjugates (e.g. dehydro...
any of various steroid acids that emulsify fats during digestion. Comparebile salt. Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
Third, combin ing these mutations by adding a G23E V211R salt bridge in LgasBSHa further lowered the preferred activity (Fig. 2i), while removing the salt bridge in LgasBSHb E21G R208V did not further decrease the preferred activity (Fig. 2j). Fourth, we created triple mutants ...
The bile salt export pump (BSEP, formerly SPGE, a sister of P-glycoprotein) is the main, if not the only, canalicular BA transporter[61], and it is also located in subcanalicular vesicles that may act as an intracellular pool. It is therefore probable that the impaired secretion of BAs...
bile duct bile salt See More Nearby Entries Cite this Entry Style “Bile duct.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/bile%20duct. Accessed 21 Jan. 2025. Copy Citation Share Post the Definition of bile duct to Facebook Facebook...
Bile, greenish yellow secretion that is produced in the liver and passed to the gallbladder for concentration, storage, or transport into the first region of the small intestine, the duodenum. Its function is to aid in the digestion of fats in the duoden
These genes encompass ATP-binding cassette, sub-family B member 11 (ABCB11), which plays a key role in the bile salt export pump, and ATP-binding cassette, sub-family B member 4 (ABCB4), which serves as a phospholipid transporter. These transporters function to decrease the levels of ...