Polycomb group (PcG) proteins and human cancers: multifaceted functions and therapeutic implications. Med. Res. Rev. 35, 1220–1267 (2015). Article CAS PubMed PubMed Central Google Scholar Zhang, W. et al. Knockdown of MMP-7 inhibits cell proliferation and enhances sensitivity to 5-...
Whether bile acids regulate biliary epithelial cell (BEC) secretory functions in human is poorly known. The purpose of the study was to determine if human gallbladder-derived BEC exhibit bile acid transport activity that affect their secretory functions and to evaluate the influence of bile acid ...
Bile is a greenish/yellowish fluid that is produced by the liver and then stored in the gallbladder. When a person eats a food that contains fat, the gallbladder is stimulated to secrete bile into the small intestine, and the bile then functions to help with the digestion of the fat....
The synthesis of primary and secondary bile acids species and how the regulation of the bile acid pool may differ between the gut and brain is discussed. The expression of several bile acid receptors in brain and their currently known functions along with the tools available to manipulate them ...
Here, we review how the signalling functions of bile acids can be exploited in the development of drugs for obesity, type 2 diabetes, hypertriglyceridaemia and atherosclerosis, as well as other associated chronic diseases such as non-alcoholic steatohepatitis. This is a preview of subscription ...
This bile duct disease was caused by the combined impairment of canonical NF-κB signaling together with inhibition of IKK1-specific functions affecting the bile-blood barrier. These results reveal a novel function of the two IκB kinases in cooperatively regulating liver immune homeostasis and bile...
Naotaka,Fujita,and,... - 《Gastrointestinal Endoscopy》 被引量: 523发表: 2003年 Manometric and radiographic evaluation of transduodenal sphincteroplasty (papillary dilation) in dogs PURPOSE: To evaluate, in dogs, the functions of biliary sphincter subjected to dilation hydrostatic balloon by the poi...
9 For this purpose, 2 functional markers were used: CLF, a green-fluorescent BA analogue; and TMRE, a mitochondrial membrane potential marker. TMRE is more abundantly taken up by periportal hepatocytes, thereby outlining the lobular zone (Fig. 2A). Within 3 min after injection into control ...
and A.M.V. For the purpose of open access, the authors have applied a CC BY public copyright to any author accepted manuscript version arising from this submission. The Department of Twin Research receives support from grants from the Wellcome Trust (212904/Z/18/Z) and the Medical Research...
Beside the oral cavity, bitter taste receptors are expressed in several non-gustatory tissues. Whether extra-oral bitter taste receptors function as sensors for endogenous agonists is unknown. To address this question, we devised functional experiments c