Fernandez-Martinez E, Perez-Alvarez V, Tsutsumi V, Shibayama M, Muriel P (2006) Chronic bile duct obstruction induces changes in plasma and hepatic levels of cytokines and nitric oxide in the rat. Exp Toxicol Pathol 58:49–58 View Article...
Currently, there is evidence that alteration in the gut ecosystem contributes to the development of liver diseases, however, the complex mechanisms involved are still unclear. We induced cholestasis in mice by bile duct ligation (BDL), mirroring the phenotype of a bile duct obstruction, to understa...
Abiliary strictureis anyblockage in the biliary tree, whether due to an obstruction within the ducts, damage of the bile duct walls, or deformities. Ablocked bile ductwill affect the outflow ofbilefrom theliverand cause it to back up in the biliary tree (cholestasis). Eventually this damage...
Related to bile duct obstruction:cholangitis,Gallstones,Bile duct cancer n. Any of the excretory passages in the liver that carry bile to the hepatic duct, which joins with the cystic duct to form the common bile duct opening into the duodenum. Also calledbiliary duct. ...
Bile duct obstruction or cholestasis can occur by several diseases or xenobiotics. Cholestasis and the accumulation of the bile constituents in the liver primarily damage this organ. On the other hand, extrahepatic organs are also affected by cholestasis. The kidney is the most affected tissue during...
nonspecific bile duct injury (mild elevation in AP or GGT) to vanishing bile duct syndrome (VBDS), sclerosing cholangitis, and cholelithiasis.10 Cholestasis may occur if there is impaired formation of bile or if there is a physical obstruction to the flow of bile after it has been secreted ...
This occurs due to obstruction to bile flow caused by the cancer cells. When bilirubin levels in the blood rise, it may also affect the color of urine, which may have a dark yellow appearance. Bile duct cancer patients complain of general muscle weakness or a decline in physical strength. ...
then their glycine conjugates, and last their taurine conjugates. Abnormalities in the size and/or composition of the bile acid pool might implicate the damage of bile acid metabolism induced by liver injury, bile duct obstruction, or gut dysbiosis....
Prolonged bile duct obstruction: A new experimental model for cirrhosis in the rat. Br J Exp Pathol 65:305-311 Kountouras, J, Billing, BH, Scheuer, PJ (1984) Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat. Br J Exp Pathol... J Kountouras,BH ...
Role of glutathione, lipid peroxidation and antioxidants on acute bile- duct obstruction in the rat. Biochimica et Biophysica Acta 1472 (1-2), 173-180, 1999.Baron V, Muriel P. Role of glutathione, lipid peroxidation and antioxidants on acute bile-duct obstruction in the rat. Biochim Biophys ...