A new bile duct ligated animal model for determining total intestinal absorption was evaluated using compounds with markedly different metabolism and excretion characteristics. Comparison of serum concentration time curves for digoxin, bumetanide, imipramine, hexobarbital, and sodium benzoate in ligated and ...
1 Bile duct ligation (BDL) Bile duct ligation (BDL) is the most widely and the longest used experimental model for cholestasis because of its high reproducibility. Originally developed in rats, this model has been then successfully adapted for mice [9,10]. This technique requires a midventral...
Animal modelAscitesBiliary cirrhosisCholestasisCommon bile duct ligationHepatopulmonary syndromeLiver diseaseMouse surgeryObstructive jaundicePortal hypertensionCholestatic liver disease covers a range of biliary disorders marked by an impaired bile duct flow. Various conditions can result in bile obstruction ...
1) bile duct ligation 胆管结扎1. The bile duct ligation (BDL) of SD rats is the most common model for experimental study of obstructive juandice. 本文采用常规的胆管结扎方法对SD大鼠进行阻黄造模,主要对手术前后的肠道菌群结构的变化进行了分子生态学研究,并与假手术组大鼠进行比较。
Farnesoid X receptor Liver failure Organic cation transporters Bile duct ligation Physiologically based pharmacokinetic model 1. Introduction The body is equipped with polyspecific organic cation transporters (OCTs), accounting for uptake, distribution and elimination of endogeneous organic cations, cationic ...
in young rats with bile duct ligation: role of protein kinase C You-Lin Tain12, Chih-Cheng Chen1, Chien-Te Lee3, Ying-Hsien Kao4, Jiunn-Ming Sheen1, Hong-Ren Yu1 and Li-Tung Huang1 Background: Bile duct ligation (BDL) is a commonly used cholestatic liver disease (CLD) model. We...
Bile duct ligation (BDL) is a commonly used cholestatic liver disease (CLD) model. We recently found that L-arginine levels were significantly raised by melatonin in young rats with BDL. We hypothesized that protein kinase C-α (PKC-α) is involved in the increases of L-arginine in melatoni...
Bile duct ligation (BDL) is a commonly used cholestatic liver disease (CLD) model. We recently found that L-arginine levels were significantly raised by melatonin in young rats with BDL. We hypothesized that protein kinase C-α (PKC-α) is involved in th
For example, liver mitochondria exposed to hydrophobic bile acids have reduced electron transport and impaired mitochondrial respiration (5,6), findings which have also been demonstrated in the bile duct-ligated model of cholestatic injury (7). Hepatocytes exposed to bile acids dem- onstrate changes...
hepatopulmonary syndrome (HPS) from the bench to the bedside using the tyrosine kinase inhibitor, sorafenib which had previously been shown to improve abnormal oxygenation and intrapulmonary shunt in a common bile duct ligation rat model. ... K Swanson - 《Liver Transplantation》 被引量: 0发表: ...