1.5.1 Surgery model The idea underlying this model is to induce a cholestasis-like condition through mechanical obstruction by knotting the bile duct with a thread. This surgical procedure is known as “bile duct ligation (BDL)”. However, the BDL technique can be further divided into the fol...
Background Several disease states commonly associated with methamphetamine (METH) use produce liver dysfunction, and in the bile duct ligation (BDL) model of hepatic dysfunction, rats with liver injury are more sensitive to METH effects. Additionally, both female rats and humans are known to be ...
1. The bile duct ligation (BDL) of SD rats is the most common model for experimental study of obstructive juandice. 本文采用常规的胆管结扎方法对SD大鼠进行阻黄造模,主要对手术前后的肠道菌群结构的变化进行了分子生态学研究,并与假手术组大鼠进行比较。
网络释义 1. 胆总管结扎 ...r系雄性鼠用于实验动物模型制作:CCl4腹腔注射和胆总管结扎(bile duct ligation BDL)诱导肝纤维化动物模型,用SABC法来检测… d.wanfangdata.com.cn|基于8个网页
The BDL groups showed stage 3 fibrosis; all the control groups were normal. NAC improved some biochemical parameters (AST, alkaline phosphatase) and oxidative stress parameters (malondialdehyde, luminol, glutathione) in the BDL model. NAC was found to be effective on cholestasis-induced hepatotoxicity...
in young rats with bile duct ligation: role of protein kinase C You-Lin Tain12, Chih-Cheng Chen1, Chien-Te Lee3, Ying-Hsien Kao4, Jiunn-Ming Sheen1, Hong-Ren Yu1 and Li-Tung Huang1 Background: Bile duct ligation (BDL) is a commonly used cholestatic liver disease (CLD) model. We...
Bile duct ligation (BDL) is a commonly used cholestatic liver disease (CLD) model. We recently found that L-arginine levels were significantly raised by melatonin in young rats with BDL. We hypothesized that protein kinase C-α (PKC-α) is involved in the increases of L-arginine in melatoni...
Bile duct ligation (BDL) is a commonly used cholestatic liver disease (CLD) model. We recently found that L-arginine levels were significantly raised by melatonin in young rats with BDL. We hypothesized that protein kinase C-α (PKC-α) is involved in th
In our study, we established the bile duct ligated model (BDL) in rats to evaluate anti-fibrotic potential of Chinese medicine sho-saiko-to (TJ-9). We assessed the drug's potential in inhibiting collagen accumulation, suppressing procollagen 伪1 types (I) and (III), and TIMP-1 mRNA ...
In sham-operated (Sham) animals, the common bile duct was exposed without ligation. The abdominal incision was closed. The rats were allowed to recover. On the 14th day following surgical operation, the BDL and Sham rats were used for the following experiments. 2.4. Pharmacokinetics of ...