Background: Bile acid malabsorption (BAM) is characterized by chronic watery diarrhea resulting from excessive bile acids in the feces. BAM is often an overlooked cause of chronic diarrhea, with its prevalence not being sufficiently researched. This review aimed to assess existing literature that ...
Conclusion Dietary intervention is an effective treatment option for patients with symptomatic bile acid malabsorption/diarrhoea and should be routinely considered. The exact fat restriction which is effective, requires further study. Disclosure of Interest None Declared 展开 ...
In addition, patients with bile acid malabsorption (e.g., in Crohn's disease or short bowel syndrome) may suffer from excessive fecal bile acid excretion and subsequently bile acid-induced diarrhea and steatorrhea due to the interrupted ileal negative feedback regulation of bile acid synthesis. ...
Define Bile acid sequestrant. Bile acid sequestrant synonyms, Bile acid sequestrant pronunciation, Bile acid sequestrant translation, English dictionary definition of Bile acid sequestrant. n. A chemical that promotes sequestration. American Heritage®
H. Westergaard Bile Acid malabsorption Curr Treat Options Gastroenterol, 10 (2007), pp. 28-33 CrossrefView in ScopusGoogle Scholar [26] A.F. Hofmann The syndrome of ileal disease and the broken enterohepatic circulation: cholerhetic enteropathy Gastroenterology, 52 (1967), pp. 752-757 View in...
a hydrophilic bile acid, and cholestyramine, a bile acid sequestrant.[12][11]However, new and emerging therapies, such as gene therapies, hepatocyte transplants, and stem cell infusions, are being developed to improve the treatment of congenital cholestatic disorders with poor morbidity and mortalit...
However, other BAs, such as ursodeoxycholic acid, have been shown to modulate BA-induced injury in hepatocytes. The major beneficial effects of treatment with ursodeoxycholic acid are protection against cytotoxicity due to more toxic BAs; the stimulation of hepatobiliary secretion; antioxidant activity,...
risk factor for MAFLD. In this review, we describe the epidemiologic evidence that links cholecystectomy to MAFLD, and discuss the possible mechanisms behind these connections, in order to unveil the metabolic and chronobiologic signals conveyed by the waves of the bile acid enterohepatic circulation....
Conclusion Dietary intervention is an effective treatment option for patients with symptomatic bile acid malabsorption/diarrhoea and should be routinely considered. The exact fat restriction which is effective, requires further study. Disclosure of Interest None Declared...
195 Similarly in humans, inherited mutations in ASBT cause significant bile acid malabsorption.196 The general consensus from these studies was that ileal active transport is the major route for conjugated bile acid uptake, whereas passive or facilitative absorption down the length of the small ...