胆汁酸(bile acids,BAs)是胆汁的主要成分之一,是以胆固醇为原料在肝脏中经一系列酶促反应合成的胆烷酸的总称,在人体脂肪代谢中起着重要作用。 目前,胆汁酸按照来源可以分成两大类,初级胆汁酸,次级胆汁酸。初级胆汁酸指在肝脏中合成的胆汁酸,主要为两种,胆酸(cholic acid,CA)和鹅脱氧胆酸(chenodeoxycholic acid,CDCA...
胆汁酸(bile acids,BAs)是胆汁的主要成分之一,是以胆固醇为原料在肝脏中经一系列酶促反应合成的胆烷酸的总称,在人体脂肪代谢中起着重要作用。 目前,胆汁酸按照来源可以分成两大类,初级胆汁酸,次级胆汁酸。初级胆汁酸指在肝脏中合成的胆汁酸,主要为两种,胆酸(cholic acid,CA)和鹅脱氧胆酸(chenodeoxycholic acid,CDCA...
1.2按化学结构分 游离胆汁酸(free bile acids):胆酸(cholic acid)、脱氧胆酸(deoxycholic acid)、鹅脱氧胆酸(chenodeoxycholic acid)、石胆酸(lithocholic acid)。 结合胆汁酸(conjugated bile acids):上述胆汁酸与甘氨酸、牛磺酸、硫酸、葡糖醛酸结合的产物。多与甘氨酸、牛磺酸结合,尤其是甘氨酸,仅有少量胆汁酸(主要...
The meaning of BILE ACID is any of several steroid acids (such as cholic acid) that occur in bile especially in the form of bile salts, are produced chiefly in the liver from cholesterol, and aid in the intestinal breakdown and absorption of fat. How to
FDA has approved cholic acid (Cholbam), a once-daily treatment for pediatric and adult patients who have bile acid synthesis disorders due to single enzyme defects. It is also approved as an adjunct to standard care for patients with peroxisomal disorders, such as Zellweger spectrum disorders....
bile acid词源英文解释 The first known use of bile acid was circa 1881 bile acid医学词典英英释义 bile acidnoun any of several steroid acids (such as cholic acid) that occur in bile especially in the form of bile salts, are produced chiefly in the liver from cholesterol, and aid in the...
4.22.3Bile Acid Conjugation 4.22.3.1Amino Acid Conjugation of Bile Acids Higher vertebrates synthesize the primarybile acids,cholic acidandchenodeoxycholic acid(the major metabolites of cholesterol), in the liver and use them to aid both the elimination of nonpolar substances in bile and the digestion...
Using rat and human hepatocytes in primary culture, we examined bile acid composition and the expression of the rate-limiting enzyme of formation, cholesterol 7α-hydroxylase. Control rat hepatocytes showed a declining bile acid production over 4 days, from 156 ± 24 ng/mL (67% cholic acid) ...
et al. Bile acid synthesis in cultured human hepatocytes: support for an alternative biosynthetic pathway to cholic acid. Hepatology 31, 1305–1312 (2000). Article CAS PubMed Google Scholar Trauner, M. & Boyer, J. L. Bile salt transporters: molecular characterization, function, and regulation...
A bile acid is any of a group of substances derived from cholesterol that play essential roles in the digestion and absorption of dietary fats and fat-soluble vitamins.