It is unclear how various bile acid biosynthetic intermediates in this pathway move from one cellular location to another. The neutral pathway of bile acid biosynthesis appears to be the major pathway of bile acid synthesis in humans under normal conditions. However, during various pathophysiological ...
To evaluate our predicted bile acid biosynthetic pathway and, in particular, the hypothesis that 3-oxo-Δ4-LCA conversion to isoalloLCA is mediated by 5AR and 3β-HSDH, we sequenced the genomes of all 68 isolates (Supplementary Table4). Sequences orthologous to human 5AR (SRD5A1) were ide...
One of the key enzymes in the bile acid biosynthetic pathways is cholesterol 7α-hydroxylase/cytochrome P450 7α-hydroxylase (7α-hydroxylase), which is the rate-limiting and regulatory step of the “classic” pathway. Transcription of the 7α-hydroxylase gene is highly regulated. Two nuclear ...
et al. Bile acid synthesis in cultured human hepatocytes: support for an alternative biosynthetic pathway to cholic acid. Hepatology 31, 1305–1312 (2000). Article CAS PubMed Google Scholar Trauner, M. & Boyer, J. L. Bile salt transporters: molecular characterization, function, and regulation...
It is well-known that in vivo TCDCA is converted into TUDCA through a five-step process for the enterohepatic circulation of bile acid [56,57,58,59,60,61,62,63] that involves the deconjugation of TCDCA by bile salt hydrolase (BSH), the 7α- or 7β-dehydroxylation of CDCA, the ...
salts and comparableKmvalues [72]. These close functional relationships between Bsep of different species are paralleled by amino acid sequence similarities of more than 80%, indicating that functional studies with rat Bsep in isolated canalicular liver plasma membrane vesicles can be extrapolated to hu...
The recovery of bile acids from the intestine is an efficient process that involves both passive transport along the entire axis of the intestine, and active transport in the terminal ileum [5]. The apical sodium/bile acid co-transporter (asbt) mediates the active uptake of conjugated bile ...
bile acid synthesis by inhibiting key enzymes involved in the biosynthetic pathway, both in cultured primary hepatocytes and in vivo. Contrarily, we observed that DMSO treatment did not confer protection against bile-acid-induced liver damage in two distinct mouse models: one induced by a 0.1% ...
Opportunities and Challenges in 2023Advances in Parenteral NutritionAdvances in Sport and Performance NutritionAdvances in Sports NutritionAdvances of Parenteral NutritionAgeing and Nutrition through LifespanAlcohol and HealthAmino Acid Nutrition and Metabolism in Health and DiseaseAnthropometry, Body Composition ...
The enhanced FCR resistance observed in SHWs, in comparison to their tetraploid progenitors, is likely a consequence of heightened responsiveness within the PAL-mediated pathways for lignin and salicylic acid synthesis.The decarbonization of various sectors relies heavily on both the efficient ...