Compression: The prepared mixtures are loaded separately through the respective doorways in a tabletting machine (e.g. MANESTY LP) and tablet compression is carried on. Reference Parameters: 1. hardness: about 5-6 kP (as sum of the double-layer hardness) 2. thickness: about 5.5 mm 3. wei...
The controlled layer was compressed and powders of the immediate release layer were added to it then both layers were compressed using a single punch tablet machine. Direct compression method was used for formulation of the bilayer tablets. The tablets were evaluated for hardness, thickness, ...
The process for preparation of bilayer pharmaceutical composition of the invention may involve wet granulation, dry granulation, direct compression, slugging, hot melt granulation, hot melt extrusion, fluidized bed granulation, extrusion-spheronization, spray drying and solvent evaporation. The wet granulat...
surface roughness analysis employing a profilometer revealed that the first layer (MF) roughness drastically decreased from 5.89 to 0.51 μm (Ra, arithmetic average of profile height deviations from the mean line) as the pre-compression pressure increased from 10 to 150 MPa in the bilayer tablet....