In mice, we induce cognitive impairment, similar to VaD in humans, by chronically reducing the cerebral blood flow by performing bilateral common carotid artery stenosis (BCAS) and administering CRex for 6 weeks. We measure behavioral changes due to cognitive function impairment ...
These findings have previously been demonstrated in a murine experimental model of CCH secondary to bilateral common carotid artery stenosis (BCAS). This study sought to elucidate the effects of CCH on recognition memory as assessed by the novel object recognition (NOR) test and histological analysis...
Here, the effects of Banhabaekchulcheonma-Tang (BBCT) on ischemic brain injury and cognitive function impairment were investigated in a bilateral carotid artery stenosis (BCAS) mouse model. Mice were divided into sham-operated, BCAS control, L-BBCT (40 ml/kg), and H-BBCT (80 ml/kg) ...
In this paper, we investigate the effects of near-infrared light therapy (NILT) for the recovery of blood flow of mice with cerebral hypoperfusion, which is a key mechanism leading to vascular dementia, induced by bilateral common carotid artery stenosis (BCAS). The mice are divided into three...
Sequential O-15-PET was also performed in a mouse model of chronic cerebral hypoperfusion with bilateral common carotid artery stenosis (BCAS) induced by placement of microcoils. O-15-gas with isoflurane was supplied to the nose of mouse with evacuation of excess O-15-gas surrounding the body...