For an early estimation of the clinical value of (potentially many) combinations of pharmacologic compounds during discovery, the observed combination effect is typically compared to that expected under a null model. Mechanistic accuracy of that null model is not aspired to; to the contrary, ...
Neuropeptide Y in the amygdala induces long-term resilience to stress-induced reductions in social responses but not hypothalamic-adrenal-pituitary axis activity or hyperthermia. J Neurosci 28: 893–903. Silberberg D, Anand NP, Michels K, Kalaria RN (2015). Brain and other nervous system ...
While Vertex suffered through layoffs, stock price plunges, and trial failures, Boger credited a focus on culture as key to its long-term success. “It’s the most important ingredient for a successful company,” he said. “Technology is acquirable. Culture is not acquirable. There are 10...
Most Americans have long assumed that they have a fundamental right to make decisions about their own bodily health and the medical treatments they receive. Informed consent is the ethical and legal principle by which that fundamental right is enforceable. To be able to give informed consent a pe...
A molecular docking verification was then performed to predict the binding affinity and the stability of the drug–protein complex. Figure 9. General overview of the research pipeline. 4.2. Differential Expression Analysis The expression profile for BRONJ was obtained from the Gene Expression Omnibus...
With the integration of an increasing number of components into blockchain systems, such as RFID, smart sensors, smart robots, biometric data, IoT, and big data, the underlying logic and implementation may become more complex. In addition, although blockchain technology is already widely applied ...
Traditional drug development process long and expensive 2nd in class only takes 4 years while 3rd in class drugs take only 1.5 years Health-in-a-fish: using a CRE system to go from disease to normal The theory is making a CRE or CURE avatar; taking a diseased zebrafish and reverse enginee...
which caused a grid failure that shut down the world’s largest petrochemical complex and caused shortages of the chemical compounds used to make an array of products. In a deeply interconnected world with inherent instabilities that include climate change, inadequate cybersecurity, non-state bad act...
HOW Having led other food accelerators, we went back to the drawing board and created a new approach to make sure you get the support you need to succeed. Our program combines capital and partnership in the form of mentor engagement, team building, peer support and access to an active netwo...
Chemical recycling is in its infancy. And many environmentalists dismiss it as a “distraction” that has yet to prove itself as anything other than an expensive niche technology — joining bioplastics and compostable alternatives that have long been hyped as offering a path to sustainability, bu...