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The class II POU domain transcription factor POU2F3 (also known as OCT11 and SKN-1a) has been reported to be a master regulator of normal and malignant tuft cell fate [17,57,58]. These chemosensory cells are found in the epithelial lining of the gastrointestinal and respiratory tracts [59...
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The authors also reported they could find a biological response to the wrong proteins in mice and in humans. They warned that these proteins “could activate T cells that target host cells,” and that their other effects “could include increased production of new B cell antigens.” T and B...
The mouse lymphoma assay is a mammalian cell mutagenicity assay that is used to determine whether a chemical is capable of inducing a mutational event in mammalian cells. Typically, mouse lymphoma L5178Y cells are used, and the ability of the cell cultures to acquire resistance to trifluorothymidi...
Effect of rituximab on the long-term outcome after high-dose therapy for relapsed B-cell non-Hodgkin's lymphoma To better define the role of rituximab in salvage and high-dose therapy (HDT) for relapsed or refractory non-Hodgkin's lymphoma (NHL), patients treated bef... G Hess,T Flohr,...
Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca2+ Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response Swi-independent 3a and 3b (Sin3a and Sin3b) are paralogous transcriptional coregulators that direct cellular differentiation...
infectious agents such as human papillomavirus and Epstein Barr virus; lifestyle factors such as low fruit and vegetable consumption; and a family history of malignancies [3,4]. Moreover, the prognosis of head and neck cancer is dismal with a five-year survival of about 50% to 60% for mos...
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