BIBN4096BS - ScienceDirectC.K. TaylorP. AbelReference Module in Biomedical Sciences
BIBN 4096BS structure CAS No. 204697-65-4 Chemical Name: BIBN 4096BS Synonyms BIBN-4096;Olcegepant;BIBN 4096BS;Olcegepant( BIBN-4096);Olcegepant, 10 mM in DMSO;BIBN 4096BS API Olcegepant;Olcegepant, CGRP antagonist;Olcegepant/BIBN-4096/BIBN 4096BS;inhibit,BIBN4096,Olcegepant,CG...
Name: BIBN 4096BS Molecular Structure: Formula: C38H47Br2N9O5 Molecular Weight: 869.65 Synonyms: BIBN 4096 BS;N-[1-[[6-amino-1-oxo-1-(4-pyridin-4-ylpiperazin-1-yl)hexan-2-yl]carbamoyl]-2-(3,5-dibromo-4-hydroxy-phenyl)ethyl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine...
Chemical NameBIBN 4096BS CAS No.204697-65-4 Molecular FormulaC38H47Br2N9O5 Molecular Weight869.64508 PSA176.47 LogP3.55 (Predicted) PubChemID6918509 Synonyms BIBN4096BS; BIBN4096BS; BIBN 4096BS; BIBN4096BS; BIBN 4096BS; 1-[3,5-Dibromo-N-[[4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl...
本发明提供用于治疗或预防头痛,偏头痛或成簇性头痛的药物组合物的第二方法,其包含有疗效量的BIBN4096BS或其生理上可接受盐及选自舒马曲坦,佐米曲坦及二氢麦角胺或其生理上可接受盐中的抗偏头痛药物(A)作为同时或相继施用的组合制剂。 根据本发明的药物组合物可包含单剂量0.1至10毫克的BIBN4096BS及单剂量1至100...
BIBN4096BS proved to be a valuable tool to dissect CGRP receptor pharmacology[1]. Interestingly, in functional assays in some tissue, the pKB values for BIBN4096BS differ depending on the agonist used, a- or -CGRP[2]. We have therefore examined the potency of BIBN4096BS to block cyclic...
7.一种用于治疗或预防头痛、偏头痛或成簇性头痛的药物组合物,其包含含有疗效量BIBN4096BS或其生理上可接受盐及一种或更多医药上可接受稀释剂和选自舒马曲坦,佐米曲坦或二氢麦角胺或其生理上可接受盐作为用于同时或相继给药的组合制剂。 8.根据权利要求7的药物组合物,其包含单一剂量单位0.1至10毫克的BBN4096BS,...
The subjects were randomly assigned to receive intravenous infusions of either placebo or one of several doses of BIBN 4096 BS. Similarly, the use of rescue medications was lower in those who received BIBN 4096 BS than in those who received placebo. At all dose levels, the difference in re...
These data suggest that BIBN4096BS could be a useful tool in further characterizing CGRP-receptor heterogeneity. Therefore, in the present study we address the effects of BIBN4096BS on the action of a- and -CGRP in four different tissues. Rat atria and vasa deferentia were employed as ...
CGRP receptor antagonist olcegepant (BIBN4096BS) does not prevent -induced .drug identificationPubmed Search Result for Nitroderm Tts