Introduction Clonal hematopoiesis with mono-allelic TP53 mutations confers a high-risk for progression to myeloid neoplasms, particularly in the context of exposure to cytotoxic stress. During leukemic transformation, bi-allelic TP53 aberrations frequently evolve - however, the exact molecular mechanisms ...
BIRC5在非小细胞肺癌中的表达及与Tp53的关系
Clinical significance of TP53, BIRC3, ATM and MAPK-ERK genes in chronic lymphocytic leukaemia: data from the randomised UK LRF CLL4 trial Stuart J. Blakemore, Ruth Clifford, Helen Parker, Pavlos Antoniou, Ewa Stec-Dziedzic, Marta Larrayoz, Zadie Davis, Latha Kadalyayil, Andrew ...
Objective: To observe the clinical effect of Tongbi Qutong ointment on acute gouty arthritis.Methods: A total of 80 patients with acute gouty arthritis were randomly divided into treatment group(n=40) and control group(n=40). Patients were treated by Tongbi Qutong ointment in treatment group...
人物简介: 一、李宁担任职务:担任安顾方胜保险经纪有限公司副董事长;二、李宁的商业合作伙伴:基于公开数据展示,李宁目前有8个商业合作伙伴,包括思勇明、韩霜、许志强等。 财产线索 线索数量 老板履历 图文概览商业履历 任职全景图 投资、任职的关联公司 商业关系图 一图看清商业版图 合作伙伴 了解老板合作关系 ...
TP53The TP53 gene is fundamental to genomic integrity, cell cycle regulation, and apoptosis; it is the most commonly mutated gene in human cancer. Heterozygous germline mutations cause the autosomal dominant cancer predisposition syndrome, Li-Fraumeni Syndrome. Homozygous germline TP53 mutations in ...
(P〈0.01);BIRC5在男性患者表达水平高于女性患者,吸烟患者中表达高于非吸烟患者,鳞癌中表达高于非鳞癌(P〈0.001).BIRC5与Tp53表达水平之间存在负相关关系(r=-0.311,P=0.011).且非参数Mann-Whiteney U检验分析显示BIRC5在Tp53高表达患者中表达高于Tp53低表达患者(P〈0.05).在I-IV期或III-IV期肺癌患者中,BIRC5...
MDM2 is a negative regulator of tumor protein 53 (TP53). We tested the in vivo efficacy of BI-907828, a small molecule inhibitor of the MDM2-TP53 interaction, in two DDLPS patient-derived xenografts (PDX).Partially immunodeficient mice were bilaterally engrafted with UZLX-STS3 ( n =24) ...
Clinical significance of TP53, BIRC3, ATM and MAPK-ERK genes in chronic lymphocytic leukaemia: data from the randomised UK LRF CLL4 trialChronic lymphocytic leukaemiaGenetics researchCancer genomicsMutational landscape of CLL4. In the Waterfall plot, known recurrently mutated genes and copy number ...
NOTCH1, SF3B1, BIRC3 and TP53 mutations in patients with chronic lymphocytic leukemia undergoing first-line treatment: correlation with biologi- cal parameters and response to treatment. Leuk Lymphoma. 2014;55(12):2785-92.Chiaretti, S.; Marinelli, M.; del Giudice, I.; Bonina, S.; Pici...