TP53The TP53 gene is fundamental to genomic integrity, cell cycle regulation, and apoptosis; it is the most commonly mutated gene in human cancer. Heterozygous germline mutations cause the autosomal dominant cancer predisposition syndrome, Li-Fraumeni Syndrome. Homozygous germline TP53 mutations in ...
Clinical significance of TP53, BIRC3, ATM and MAPK-ERK genes in chronic lymphocytic leukaemia: data from the randomised UK LRF CLL4 trial Stuart J. Blakemore, Ruth Clifford, Helen Parker, Pavlos Antoniou, Ewa Stec-Dziedzic, Marta Larrayoz, Zadie Davis, Latha Kadalyayil, Andrew ...
BIRC5在非小细胞肺癌中的表达及与Tp53的关系
aWe postulate that a mutation in the TP53 gene results in a decreased inhibition and consequently an upregulation of FOXM1, TPX2, BIRC5 and TOP2A. 我们假设一个变化在TP53基因导致减少的禁止和因而FOXM1、TPX2、BIRC5和TOP2A的upregulation。 [translate] ...
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Objective: To observe the clinical effect of Tongbi Qutong ointment on acute gouty arthritis.Methods: A total of 80 patients with acute gouty arthritis were randomly divided into treatment group(n=40) and control group(n=40). Patients were treated by Tongbi Qutong ointment in treatment group...
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MDM2 is a negative regulator of tumor protein 53 (TP53). We tested the in vivo efficacy of BI-907828, a small molecule inhibitor of the MDM2-TP53 interaction, in two DDLPS patient-derived xenografts (PDX).Partially immunodeficient mice were bilaterally engrafted with UZLX-STS3 ( n =24) ...
(P〈0.01);BIRC5在男性患者表达水平高于女性患者,吸烟患者中表达高于非吸烟患者,鳞癌中表达高于非鳞癌(P〈0.001).BIRC5与Tp53表达水平之间存在负相关关系(r=-0.311,P=0.011).且非参数Mann-Whiteney U检验分析显示BIRC5在Tp53高表达患者中表达高于Tp53低表达患者(P〈0.05).在I-IV期或III-IV期肺癌患者中,BIRC5...
Clinical significance of TP53, BIRC3, ATM and MAPK-ERK genes in chronic lymphocytic leukaemia: data from the randomised UK LRF CLL4 trialChronic lymphocytic leukaemiaGenetics researchCancer genomicsMutational landscape of CLL4. In the Waterfall plot, known recurrently mutated genes and copy number ...