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In vivo inhibition of NE and NSP proteinase 3 (PR3) in bronchoalveolar lavage fluid (BALF) neutrophils after lipopolysaccharide (LPS) challenge and distribution of BI 1291583 was determined in a mouse model.Results BI 1291583 bound human CatC in a covalent, reversible manner, selectively and fully...
BI 1291583: a novel selective inhibitor of cathepsin C with superior in vivo profile for the treatment of bronchiectasis BI 1291583 exhibited up to 100 times the exposure in the target tissue bone marrow compared with plasma.Conclusion BI 1291583-mediated inhibition of CatC ... K Stefan,S ...
P094 A Phase II study to evaluate the safety, tolerability, pharmacodynamics and pharmacokinetics of BI 1291583 in patients with cystic fibrosis bronchiectasis (the Clairafly study) 来自 dx.doi.org 喜欢 0 阅读量: 3 作者: MA Mall,W Sauter,JC Davies,S Donaldson,A Eleftheraki,D Sarubbi,T Sch...