Here, we reveal multiple domains in the 3.6-Å Cryo-EM structure of BIRC6, which forms an anti-parallel U-shaped dimer, in addition to the two sets of BIR and UBC located next to each other, and provide the molecular mechanisms for the BIRC6-mediated regulation of apoptosis and ...
Science 333, 453–456 (2011). Article CAS Google Scholar Garcia-Pino, A., Zenkin, N. & Loris, R. The many faces of Fic: structural and functional aspects of Fic enzymes. Trends Biochem. Sci. 39, 121–129 (2014). Article CAS Google Scholar Roy, C.R. & Cherfils, J. Structure...
67, 447–456 (1994) Google Scholar Wang, Y., Rudy, Y.: Action potential propagation in inhomogeneous cardiac tissue: safety factor considerations and ionic mechanism. Am. J. Physiol. Heart Circ. Physiol. 278, H1019–H1029 (2000) Google Scholar Wang, D., Kirby, R.M., Johnson, C....
It was reported that low molecular weight hyaluronan enhanced cell motility and angiogenesis, while high molecular weight hyaluronan was anti-angiogenic, anti-inflammatory, and suppressed tumorigenesis and CD44-mediated breast cancer cell invasion [456]. Therefore, hyaluronan with the right molecular...
Download: Download high-res image (456KB) Download: Download full-size image Figure 7. 3ʹ-UTR-Dependent Protein Interactors Have the Potential to Be Widespread (A) 3ʹ-UTR-independent BIRC3 functions are mediated by 3ʹ-UTR-independent protein interactors (brown), including XIAP, DIABLO,...
Secreted proteins are one of the direct molecular mechanisms by which microbiota influence the host, thus constituting a promising field for drug discovery. Here, through bioinformatics-guided screening of the secretome of clinically established probioti
2008;50:456-60. II. Complications After Percutaneous Coronary intervention (PCI) and endovascular surgery for Peripheral Artery Disease (PAD) (a) after prior PCI, and (b) after prior PAD Endovascular Interventions: Carotid Artery Endarterectomy II(a) PCI After Prior PCI – Major occurring ...
Disease Biology, Small Molecules in Development of Therapeutic Drugs,Frontiers in Cardiology and Cardiovascular Disorders,Genome Biology,Genomic Testing: Methodology for Diagnosis,Health Economics and Outcomes Research,HTN,Interviews with Scientific Leaders,Medical and Population Genetics,Molecular Genetics & ...
A total of 50 µg protein extracts from tumor and normal samples were separated by 8–16% gel (BioRad, Cat# 456-1104) and transferred onto activated PVDF membranes (Millipore, Immobilon-P, #IPVH00010 and ISEQ00010) with Towbin buffer (25 mM Tris, 192 mM Glycine, 10% ...
Hoeben, R.C., et al., “Expression of Functional Factor VIII in Primary Human Skin Fibroblasts after Retrovirus-mediated Gene Transfer,” The Journal of Biological Chemistry 265(13):7318-7323, The American Society for Biochemistry and Molecular Biology, United States (1990). Holt, L.J., et...