FDA requires several changes to bevacizumab label to include safety informationSafety information chagnes to the package insert for bevacizumab were issued by FDA on September 30, 2011.doi:http://formularyjournal.modernmedicine.com/node/138820F. Staff...
in the package insert, and atwww.gene.com/download/pdf/avastin_prescribing.pdf.12Bevacizumab is generally given at a dosage of 10 mg/kg every 14 days on a 28-day cycle; two infusions constitute one cycle. The maximal tolerable dose is about 15 to 20 mg/kg; the optimal biologic dos...
the toxicities of bevacizumab in ovarian cancer patients, and their management.7 Table 2 lists the adverse effects that were included in the FDA-approved bevacizumab package insert.28 The most common toxicities include hypertension (grade 3–4 ranging from 0.3% to 14.8% of patients),...