BETA-LACTAM ANTIBACTERIALS, MANUFACTURE AND COMPOSITIONA compound of formula (1) or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof: ##STR1## wherein R.sup.1 is phenyl, substituted phenyl or a 5- or 6-membered heterocyclic ring containing up to three heteroatoms ...
Beta-lactamase inhibitors enhance the activity of beta-lactam antibacterials against beta-lactamase-producing bacteria. These agents cause irreversible inhibition of many plasmid-mediated and some chromosomal beta-lactamases. They result in successful inhibition of beta-lactamases produced by gram-positive bac...
athe report compares the different types of home computers available in market 报告比较家庭计算机的不同的类型可利用在市场上[translate] aOTHER BETA-LACTAM ANTIBACTERIALS 其他BETA-LACTAM抗菌[translate]
7 carbocyclic ring; except all isomers of thienamycin and except compounds wherein R2 is ethyl or 1-hydroxyethyl and R, is 尾-aminoethyl or 尾-acetamidoethyl and except compounds wherein R2 is isopropyl and R1 is trans 尾-acetamidoethyl, are antibacterials. Their preparation and...
Kumar, P. et al. Non-classical transpeptidases yield insight into new antibacterials.Nat. Chem. Biol.13, 54–61 (2017). ArticleCASGoogle Scholar Peters, K. et al. Copper inhibits peptidoglycan LD-transpeptidases suppressing β-lactam resistance due to bypass of penicillin-binding proteins.Proc....
with certain beta-lactam antibacterials extends their activity against bacteria that are normally resistant to the antibiotic due to production of beta-... DM Campoli-Richards,RN Brogden - 《Drugs》 被引量: 140发表: 1987年 Beta-Lactam-beta-lactamase-inhibitor combinations are active in experimental...
A novel family of &bgr;-lactam antibacterials, synthetic methods and intermediates useful in the production of such antibacterials, and the use of such compounds as antibacterials are disclosed. The novel compounds have the formula ##STR1## wherein, Z.sup.1 is a group --OR.sup. 1, --NR...
DE2727586A1 * 1977年6月20日 1979年1月4日 Bayer Ag Beta lactam antibacterials - with 2-oxo-imidazolidine type substit. in the side chain, are useful e.g. for increasing growth rate of animals
A novel family of &bgr;-lactam antibacterials, synthetic methods and intermediates useful in the production of such antibacterials, and the use of such compounds as antibacterials are disclosed. The novel compounds have the formula ##STR1## wherein, Z.sup.1 is a group --OR.sup. 1, --NR...
(I) having a 3-acylamino substit. are antibacterials effective against Gram negative and positive species, and useful therapeutically in human or veterinary medicine. The other new cpds. are intermediates.