Cadmium (Cd) is a transition heavy metal that is able to accumulate in the central nervous system and may induce cell death through reactive oxygen species (ROS)-mediated mechanisms and inactivating the antioxidant processes, becoming an important risk factor for neurodegenerative disease...
CB2 receptors are expressed in the hippocampus, which is heavily involved in learning and memory, as well as the ventral tegmental area, which is a major player in neural circuits of pleasure and reward.1,2 CB2 receptors are also expressed in immune cells and peripheral nervous system path...
It is an agonist of the cannabinoid (CB) receptor CB2 (Ki = 155 nM) that inhibits cAMP production induced by forskolin in CHO-K1 cells expressing CB2 receptors (EC50 = 38 nM). β-Caryophyllene is also an agonist of peroxisome proliferator-activated receptor α (PPARα; EC50 = 9.58 μM ...
Beta-caryophyllene (BCP) is a natural compound that selectively binds to CB2 receptors, providing anti-inflammatory effects without the psychoactive effects associated with CB1 receptor activation. By regulating the ECS, particularly through CB2 receptor activation, BCP shows potential in ameliorating inflam...
Progress in brain cannabinoid CB2 receptor research: From genes to behavior. Neurosci Biobehav Rev. 2019;98:208–20. CAS PubMed PubMed Central Google Scholar Mediavilla V, Steinemann S. Essential oil of cannabis sativa L. strains. I Int Hemp Res. 1997;4:80–2. Google Scholar Sharma C,...
BCP was previously reported to be a selective CB2 receptor agonist. Unexpectedly, pharmacological blockade or genetic deletion of CB1, CB2, or GPR55 receptors in gene-knockout mice failed to alter BCP's action against cocaine self-administration, suggesting the involvement of non-CB1, non-CB2, ...
A CB2 receptor antagonist (AM 630), but not a CB1 receptor antagonist (AM 251), antagonized BCP attenuation of established ddC-induced mechanical allodynia. beta-Caryophyllene prevented the ddC-induced increase in cytokine (interleukin 1 beta, tumor necrosis factor alpha and interferon gamma) ...
β-caryophyllene; NAFLD; steatosis; lipid profile; CB2 receptors; PPARγ; PPARα; HepG2 cell line1. Introduction Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder, with an average prevalence of 25%, ranging from 13% (adult African population) to 32% (...
Betacaryophyllene, a phytocannabinoid acting on CB2 receptorsZimmer, ARacz, IKlauke, ALMarkert, AGertsch, J
beta-Caryophyllene, a natural bicyclic sesquiterpene attenuates doxorubicin-induced chronic cardiotoxicity via activation of myocardial cannabinoid type-2 (CB2) receptors in ratsDoxorubicinCardiotoxicitybeta-CaryophylleneCannabinoid 2 receptorAM630The cannabinoid type 2 receptor (CB2) has recently emerged as an ...