Beta thalassemia trait ranks second to iron deficiency as the most frequent cause of anemia of pregnancy in our clinic. The anemia of patients with thalassemia trait increases during the second trimester, as does that with normal controls. This is not sufficient to result in any disability or ...
Because of chronic anemia, hypogonadotropic hypogonadism, and iron chelation, pregnancy in homozygous and heterozygous compound beta-thalassemia patients s
Dr. Neel recognized that the parents of children with thalassemia major had thalassemia minor with one beta thalassemia gene. When these parents had children, they had a 25% chance of having a thalassemia major child (with both genes for beta thalassemia), a 50% chance of having children with...
Beta-thalassemia is caused by the reduced (beta+) or absent (beta0) synthesis of the beta globin chains of the hemoglobin tetramer. Three clinical and hematological conditions of increasing severity are recognized, i.e., the beta-thalassemia carrier state, thalassemia intermedia, and thalassemia ma...
Beta-thalassemia associated with other features In rare instances the beta-thalassemia defect does not lie in the beta globin gene cluster. In cases in which the beta-thalassemia trait is associated with other features, the molecular lesion has been found either in the gene encoding the transcripti...
Antenatal screening for beta thalassemia trait (BTT) followed by counseling of couples is an efficient way of thalassemia control. Since high performance liquid chromatography (HPLC) is costly, other cost-effective screening methods need to be devised for this purpose. The present study was aimed ...
Adults in a health maintenance organization, unselected for interest, were screened for beta-thalassemia trait as part of preventive health care. Counseling was provided by either a trained physician (conventional counseling) or by a videotape containing the same information followed by an opportunity ...
- Thalassemia trait (BTT) in a medical students of Karachi, Pakistan and to confirm the validity of Naked Eye Single Tube Red cell Osmotic Fragility Test (NESTROFT) to qualify for a mass screening test for BTT detection. SETTING: An analytical cross sectional study, performed from Jan 2010 ...
Thalassemia major is one of the most common genetic disorders in Pakistan and over five thousand new patients are added in the pool annually. This familial disease has both medical and social implications, and therefore there is a need to assess the magnitude of beta-Thalassemia trait amongst fam...
Quantities of alpha Q chain variants in heterozygotes with and without a concomitant beta-thalassemia trait. 来自 Wiley 喜欢 0 阅读量: 8 摘要: We have analyzed the quantities of x chain-containing hemoglobins (x2 and 2x2,) in 14 heterozygotes for Hb Q-India [64(E13)AspHis] or Hb Q-...