BETA-ThalassemiaMYCOPLASMA pneumoniae infectionsAUTOIMMUNE hemolytic anemiaANEMIAKLEBSIELLA infectionsEditor An 83-year-old man with a history of beta-thalassemia trait (baseline haemoglobin 10 g/dl), coronary artery disease on aspirin, and prior gastrointestinal (GI) bleeds presented to the emergency ...
Beta thalassaemia heterozygotes typically have erythrocytes with smaller mean corpuscular volume (MCV) and mean corpuscular haemoglobin than wild type cells10. Known alterations to the membrane of red blood cells in beta thalassaemia heterozygotes include an increase in the flux of K+across the membran...
Beta-thalassemia is caused by the reduced (beta+) or absent (beta0) synthesis of the beta globin chains of the hemoglobin tetramer. Three clinical and hematological conditions of increasing severity are recognized, i.e., the beta-thalassemia carrier state, thalassemia intermedia, and thalassemia ma...
Divoky V, Svobodova M, Indrak K, Chrobak L, Molchanova TP, Huisman TH: Hb Hradec Kralove (Hb HK) or alpha 2 beta 2 115(G17)Ala-->Asp, a severely unstable hemoglobin variant resulting in a dominant beta-thalassemia trait in a Czech family. Hemoglobin. 1993 Aug;17(4):319-28. [Arti...
Related to Beta thalassemia:Alpha Thalassemia thal·as·se·mi·a (thăl′ə-sē′mē-ə) n. An inherited form of anemia occurring chiefly among people of Mediterranean descent, caused by faulty synthesis of part of the hemoglobin molecule. Also calledMediterranean anemia. ...
Jorge Mansilla-Soto, Genetic strategies for the treatment of sickle cell anaemia, British Journal of Haematology, 154, 715-727 (2011). Alessia Finotti, Recent trends in the gene therapy of β-thalassemia, Journal of Blood Medicine 2015:6 69-85 (2015). Yongliang Huo, Humanized Mouse Model...
β-Thalassemia traitIron deficiency anemiaRDWRDWIMentzer’s indexIntroduction: Beta thalassaemia trait (β-TT) and iron deficiency anaemia (IDA) are the most frequent causes of hypochromic microcytic anaemia in Bangladesh. Differentiation between βTT and IDA is important for proper treatment of ...
β-Thalassemia traitIron deficiency anemiaRDWRDWIMentzer’s indexIntroduction: Beta thalassaemia trait (β-TT) and iron deficiency anaemia (IDA) are the most frequent causes of hypochromic microcytic anaemia in Bangladesh. Differentiation between βTT and IDA is important for proper treatment of ...
Del Giudice EM, Perrotta S, Nobili B, Pinto L, Cutillo L, Iolascon A (1993) Coexistence of hereditary spherocytosis (HS) due to band 3 deficiency and β thalassemia trait; partial correction HS of phenotype. Br J Haematol 85:553–557...
ThalassemiaIron deficiencyAnaemiaDiscriminant indexMSI-scoreMSI indexSeveral studies have stablished discriminant formulas (DF) from red blood cell (RBC) data as simple, low time-consuming and inexpensive tools to differentiate β-thalassemia trait (β-TT) from iron deficiency anaemia (IDA). The aim...