Beta-thalassemia is caused by the reduced (beta) or absent (beta) synthesis of the beta globin chains of the hemoglobin tetramer. Three clinical and hematological conditions of increasing severity are recognized, i.e., the beta-thalassemia carrier state, thalassemia intermedia, and thalassemia major...
Beta-thalassemia is caused by the reduced (beta+) or absent (beta0) synthesis of the beta globin chains of the hemoglobin tetramer. Three clinical and hematological conditions of increasing severity are recognized, i.e., the beta-thalassemia carrier state, thalassemia intermedia, and thalassemia ma...
Beta-thalassemia major (β-TM) patients are more likely to experience blood glucose intolerance and to date; the blood markers that could evaluate this are debatable. So, this study aimed to assess the roles of glycated hemoglobin A1c (HbA1c) and fructosamine in evaluating glucose intolerance in...
Because total cholesterol levels have been found to be lower in patients affected by thalassemia major and intermedia, we examined the plasma lipid pattern of 628 beta-thalassemia trait carriers and 4552 controls in order to evaluate whether the plasma lipid impairment is also present in the heteroz...
Gap-PCR was performed in order to detect common alpha thalassemia determinants (±3.7, ±4.2 and ±±±anti 3.7 triplication). Alpha-triplication was detected in 15.4% (10/65) of patients with thalassemia intermedia, 8.8% (4/45) of those with thalassemia minor and in 2.7% (2/74) of ...
The term thalassemia is derived from the Greek, thalassa (sea) and haima (blood). Beta-thalassemia includes three main forms: Thalassemia Major, variably referred to as "Cooley's Anemia" and "Mediterranean Anemia", Thalassemia Intermedia and Thalassemia Minor also called "beta-thalassemia carrier"...
mutations, associated 卤-thalassemia, and XmnI polymorphism in the gamma globin gene, which are known to affect the clinical course of the disease, were investigated from 15 homozygous 0-thalassemia patients comprising 11 patients with -thalassemia major and 4 patients with -thalassemia intermedia. ...
MRI is a useful modality in diagnosis and surveillance of these patients. quot;nKeywords: Hydroxyurea, MRI, Extramedullary hematopoiesis, Beta Thalassemia Intermedia amp;nbsp;Mojtahedzadeh FKosaryan MKowsarian SASTehran University of Medical Sciences...
Because of chronic anemia, hypogonadotropic hypogonadism, and iron chelation, pregnancy in homozygous and heterozygous compound beta-thalassemia patients s
Beta-thalassemia. N. Engl. J. Med. 353, 1135–1146 (2005). Article CAS PubMed Google Scholar Asadov, C. et al.β-Thalassemia intermedia: a comprehensive overview and novel approaches. Int. J. Hematol. 108, 5–21 (2018). Article CAS PubMed Google Scholar Ursi, W. J., Trotman,...