Evaluation of hemoglobin agarose electrophoresis and Hb-F alkali denaturation test in diagnosis of β-Thalassemia; 全自动血红蛋白电泳与Hb-F碱变性试验在β地中海贫血中的应用及评价 3) Beta-thalassemia β地中海贫血 1. Amniotic fluid gene detection in prenatal diagnosis of alpha-and beta-thalassemia; ...
β-ThalassemiaErythroid cell cultureGlobin chain synthesisHb EHemoglobin synthesis in a 34-year-old man of Laotian ancestry with Hb thalassemia was studied. Hemoglobin electrophoresis exhibited only Hb F and Hb E. Reticulocytes and bone marrow cells showed no Hb A synthesis. The proportion of Hb ...
India, Southern China, and the Far East as well as countries along the north coast of Africa and in South America. The highest carrier frequency is reported in Cyprus (14%), Sardinia (10.3%), and Southeast Asia [1]. The high gene frequency of beta-thalassemia in these regions is most ...
Hb pattern (by cellulose acetate electrophoresis or high-performance liquid chromatography [HPLC]) varies according to the type of beta-thalassemia. In beta0-thalassemia, characterized by the lack of beta globin chain synthesis, HbA is absent, HbF is 95–98%, and HbA2is 2–5%. In beta+-tha...
Beta-thalassemia major (β-TM) patients are more likely to experience blood glucose intolerance and to date; the blood markers that could evaluate this are debatable. So, this study aimed to assess the roles of glycated hemoglobin A1c (HbA1c) and fructosamine in evaluating glucose intolerance in...
One infant was thought to have the beta-thal trait but had a greater degree of thalassemic changes in red cells; subsequently he turned out to have homozygous beta-thalassemia. Four newborn infants with hypochromia and numerous target cells had 4-7% Hb E + Hb F without Hb A. Follow-up ...
Conculsions The area under the ROC curve shows that the Sebia automatic capillary electrophoresis system has high accuracy in screening beta thalassemia, the Hb A2 cutingt off value is more than 3.85 %.supports all the CNKI file formats;only supports the PDF format. 展开 ...
beta-Thalassemia is the most frequent monogenic disorder in the country. Analysis of hemoglobin of 435 cases from Eastern India was performed by electrophoresis and by other quantitative methods. Analysis of the beta-globin gene of 112 cases used ARMS (amplification refractory mutation system)-PCR (...
Thalassemia refers to any of several genetic defects in the production of globin chains of Hb. Patients may have deficient production of the α-globin chain (α thalassemia) or the β-globin chain (β thalassemia). The clinical thalassemic syndromes can be understood in terms of the correspon...
Alter BP, Coupal E, Forget BG. Globin chain electrophoresis for prenatal diagnosis of beta thalassemia. Hemoglobin. 1981; 5 (4):357–370. [ PubMed ]Alter BP, Coupal E, Forget BG. Globin chain electrophoresis for prenatal diagnosis of beta thalassemia. Hemoglobin. 1981; 5 (4):357–370....