Sickle cell disease and sickle beta-thalassemia : clinical features / G. Graziadei, M. Soldarini, C. Cesaretti, C. Refaldi, M. Salvatori, E. Cassinerio, M. D. Cappellini. - In: Haematologica. - ISSN 0390-6078. - ISSN 1592-8721. - 96:Suppl. 3(2011 Oct), pp. 14-14. ((...
GENETEST REVIEW Genetics in Medicine Beta-thalassemia Antonio Cao, MD1, and Renzo Galanello, MD2 TABLE OF CONTENTS Clinical Features ...62 Beta-thalassemia major ...62 Beta-thalassemia intermedia ...
Beta-thalassemia is prevalent in Mediterranean countries, the Middle East, Central Asia, India, Southern China, and the Far East as well as countries along the north coast of Africa and in South America. The highest carrier frequency is reported in Cyprus (14%), Sardinia (10.3%), and Southe...
Beta-thalassemias are a group of hereditary blood disorders characterized by anomalies in the synthesis of the beta chains of hemoglobin resulting in variable phenotypes ranging from severe anemia to clinically asymptomatic individuals. The total annual incidence of symptomatic individuals is estimated at ...
The prevalence of β-thalassemia in Mexico is not known in detail. Data of studies investigating abnormal hemoglobins between September 1987 and November 2000 were analyzed; in addition, data of red-blood-cell indices and clinical features were analyzed in patients identified as carriers of β-thal...
The prevalence of Sβ-thalassemia was reported to be less than one-third to zero percent of sickle-cell cases [3, 4]. Clinical features may vary from a sickle cell anemia-like condition to an asymptomatic condition depending on the inherited type of β-thalassemia (βo,β+,β++) [5]....
Beta-thalassemia is caused by the reduced (beta+) or absent (beta0) synthesis of the beta globin chains of the hemoglobin tetramer. Three clinical and hematological conditions of increasing severity are recognized, i.e., the beta-thalassemia carrier state, thalassemia intermedia, and thalassemia ma...
Sickle Cell Beta Thalassemia is a condition characterized by the inheritance of one β S gene and a thalassemia defect on the other β gene, resulting in variable amounts of protein production and similarities to sickle cell anemia in hematology and prognosis. ...
Beta-thalassemia is caused by the reduced (beta) or absent (beta) synthesis of the beta globin chains of the hemoglobin tetramer. Three clinical and hematological conditions of increasing severity are recognized, i.e., the beta-thalassemia carrier state, thalassemia intermedia, and thalassemia major...
The hematological data of II5 corresponds to a intermediate thalassemia with not transfusion dependent feature an opposite to II1 that presents a heterozygous thalassemic trait features with 4 alpha genes.The phenotypical expression of the different interactions of these mutations in this family, points...