Co-Inheritance of Beta & Delta-Globin Gene (HbYialousa) Mutations in an Iranian 尾 -Thalassemia Carrier[J] . Atefeh Valaei,Farnaz Eghbalpour,Zahra Kainimoghaddam,Fatemeh Bayat,Maryam Taghavi Basmanj,Morteza Karimipoor,Sirous Zeinali.International Journal of Clinical Medicine . 2012 (07)...
The term thalassemia is derived from the Greek, thalassa (sea) and haima (blood). Beta-thalassemia includes three main forms: Thalassemia Major, variably referred to as "Cooley's Anemia" and "Mediterranean Anemia", Thalassemia Intermedia and Thalassemia Minor also called "beta-thalassemia carrier",...
Beta-thalassemia is caused by the reduced (beta+) or absent (beta0) synthesis of the beta globin chains of the hemoglobin tetramer. Three clinical and hematological conditions of increasing severity are recognized, i.e., the beta-thalassemia carrier state, thalassemia intermedia, and thalassemia ma...
Significance of borderline HbA2 levels in β thalassemia carrier screening Article Open access 30 March 2022 Abnormal hemoglobin anti-Lepore Hong Kong compound with β0-thalassemia ameliorate thalassemia severity when co-inherited with α-thalassemia Article Open access 20 March 2024 A novel compou...
Balearic archipelago: three islands, three beta-thalassemia population patterns.The mutation spectrum of 175 β-thalassemia (β-thal) carriers, identified in pilot carrier screening on 22,713 individuals from Balearic Islands (Spain), is reported. The β0 CD39 (C>T) mutation is the most ...
Carriers are often referred to as having thalassemia minor (or β-thalassemia minor). Carrier testing for individuals at risk (including family members, gamete donors, and members of at-risk populations) is possible. Prenatal testing for pregnancies at increased risk is possible if the disease-...
Carrier screening and prenatal diagnosis have been widely performed in China to prevent the birth of children with homozygous α0‐and β-thalassemias. Mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) are the most commonly used indicators for β-thalassemia screening, with low va...
Related to Beta thalassemia:Alpha Thalassemia thal·as·se·mi·a (thăl′ə-sē′mē-ə) n. An inherited form of anemia occurring chiefly among people of Mediterranean descent, caused by faulty synthesis of part of the hemoglobin molecule. Also calledMediterranean anemia. ...
In vitro Hb chain biosynthesis was studied in all subjects, and both parents had an .alpha./non-2 ratio typical of .beta.-thalassemia. The mother is apparently a silent carrier of the triat. The daughters and the son have a less severe Cooley disease due to this double heterozygosity. ...
Beta thalassemia is a group of genetic blood disorders that share in common the defective production of hemoglobin, similar to sickle cell. Learn about symptoms, treatment, who is a carrier, and diagnosis for beta thalassemia.