The active compound was identified as β-sitosterol based on gas chromatography retention times and electron ionization mass spectroscopy (EI-MS) spectrum of authentic β-sitosterol. Authentic β-sitosterol restored GJIC in the tumorigenic WB-Ha-ras GJIC-deficient cells at a dose of 2.4 μM. In ...
The obtained mass spectrum was matched with scientific literatures and active constituents were identified. The cytotoxicity of active compounds was assessed by MTT assay. Statistical analysis All the experiments were conducted in triplicate (n = 3) and one-way ANOVA (using SPSS 17 statistical ...
Synthetically, it is synthesized from stigmasterol by Δ22–23 alkene group hydrogenation. Structurally sitosterol differ from cholesterol with ethyl (sitosterol) group in C24 position of side chain(65). Sitosterol is a lipid component of membranes. It corresponds to a molecular mass of 414.71 g/...
Mass spectrum (electron ionization)收起↑ 计算化学数据 分子量:412.69082g/mol 化合物是否规范:True 疏水参数计算参考值(XLogP3-AA):9.3 准确质量:412.370516150 同位素质量:412.370516150 复杂度:674 可旋转化学键数量:6 氢键供体数量:0 氢键受体计数:1
10α-methoxyartemisinic acid (Kun et al., 2016) and costunolide, dehydrocostuslactone along with costic, palmitic, linoleic acids, β-sitosterol, α-cyclocostunolide, β-cyclocostunolide, alantolactone, isoalantolactone and isodihydrocostunolide were also isolated (Robinson et al., 2008; Guang et al...
(gemfibrozil, clofibrate, fenofibrate and bezafibrate), (v) PPARα/γ dual agonists, such as KRP-297, (vi) inhibitors of cholesterol absorption, such as beta-sitosterol and ezetimibe, (vii) acyl CoA:cholesterol acyltransferase inhibitors, such as avasimibe, and (viii) anti-oxidants, such as...
medicines Review Critical Analysis on Characterization, Systemic Effect, and Therapeutic Potential of Beta-Sitosterol: A Plant-Derived Orphan Phytosterol Muhammad Shahdaat Bin Sayeed 1,*, Selim Muhammad Rezaul Karim 2,3, Tasnuva Sharmin 3 and Mohammed Monzur Morshed 4 1 Department of Clinical ...
Compound (1), stigmasterol, isolated as a white amorphous powder with a melting point of 170 °C, was identified based on spectral data, which were similar to β-sitosterol, compound (2); except for the presence of two multiple olefinic protons at δH5.03 and δH5.20, in addition to the...
The ECNI mass spectrum of the cholesta-3β,5α,6β-triol trifluoroacetate derivative (Figure 2C) appeared to be dominated by a peak at m/z 113 corresponding to the anion CF3-COO− and a smaller molecular peak at m/z 708, attesting that the observed derivative was well triacetylated. ...
The drugs delivery system in the treatment of diseases has advantages such as reduced toxicity, increased availability of the drug, etc. Therefore, studies of the supramolecular interactions between local anesthetics (LAs) butamben (BTB) or ropivacaine (