www.nature.com/scientificreports OPEN received: 16 June 2015 accepted: 28 October 2015 Published: 02 December 2015 Alzheimer therapy with an antibody against N-terminal Abeta 4-X and pyroglutamate Abeta 3-X Gregory Antonios1,*, Henning Borgers1,*, Bernhard C. Richard1, Andreas ...
www.nature.com/scientificreports OPEN received: 16 June 2015 accepted: 28 October 2015 Published: 02 December 2015 Alzheimer therapy with an antibody against N-terminal Abeta 4-X and pyroglutamate Abeta 3-X Gregory Antonios1,*, Henning Borgers1,*, Bernhard C. Richard1, Andreas ...
准备证书 AI检测代码解析 cat << EOF | tee /apps/work/k8s/cfssl/k8s/dashboard.json { "CN": "dashboard", "hosts": [""], "key": { "algo": "rsa", "size": 2048 }, "names": [ { "C": "CN", "ST": "GuangDong", "L": "GuangZhou", ...
Extracellular senile plaques and intracellular neurofibrillary tangles are the neuropathological findings of the Alzheimer’s disease (AD). Based on t
and RNA polymerase II on ERα-repressed genes, which leads to the epigenetic activation of H3K4me3-related suppressor gene transcription, thus promotingP53-based tumor suppression. ERβ also attenuates the crosstalk between ERα andP53by reducing corepressor NCoR and SMRT recruitment by ERα [125]....
In addition, tau protein becomes hyperphosphory- lated in response to kinase/phosphatase activity changes mediated by Aβ aggregation, leading to the formation of neu- rofibrillary tangles (NFTs), neuronal and eventual synaptic dysfunction, and finally Alzheimer's disease (Figure 4). When the ...
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