Heating 2-hydrazino-1H-benzoimidazole 200 with trifluoroacetoacetic acid ester 201 under acidic conditions results in a mixture of two compounds: the linear product 202 and the subsequent isomeric-cyclized pyrazole-derived product 203 (Equation (75)) <2001CHE120>. (75) Treatment of pyran-2-one...
Some prodrugs have a chemical group present on the prodrug that renders it less active and/or confers solubility or some other property to the drug. Once the chemical group has been cleaved and/or modified from the prodrug the active drug is generated. Prodrugs are often useful because, in ...