1.Tomasterthemechanismofactionandthebacterialresistanceofβ-lactamantibiotics.2.Tomastertheantibacterialspectrum,clinicaluse,adversereactionsandprophylacticmeasuresofpenicillinG.3.Tomastertheantibacterialspectrum,clinicaluse,adversereactionsoffourgenerationsofcephalosphorins.4.Familiarwiththecharacteristicsandclinicalusesof...
IV, fourth-generation drug, broad activity with improved stability to chromosomal B-lactamase Cefepime (maxipime) Type of Cephalosporin:IV, active against methicillin-resistant staphylococci, broad gram-negative activity not including Pseudomonas Ceftaroline (Teflaro) Mechanism of Action:Prevents bacterial c...
MECHANISM OF ACTION: Beta-lactamase inhibitors inactivate these enzymes and, in association with beta-lactamines, offer wide spectrum bactericidal action (Gram negative bacilli, anaerobic germs, methicillin-sensitive staphylococci and streptococci) and can be used as first-line treatment in certain ...
c.Mechanism of β-lactamase action i.Kinetics of acyl-enzyme catalysis. β-Lactamase converts penicillin (or cephalosporin) [S] to the biologically inactive penicilloic (or cephalosporoic) acid [P] via an acyl-enzyme intermediate (E-acyl) (Scheme 8.2). ...
Identification of residues critical for catalysis in a class C beta-lactamase by combinatorial scanning mutagenesis.Carbon ionCatalysisbeta-LactamasesActive SiteMutagenesis催化作用β内酰胺酶类诱变Despite their clinical importance, the mechanism of action of the class C beta-lactamases is poorly understood. ...
ANTIBIOTICS–mechanismofaction β-lactams,Glycopeptides 30S:Aminoglycosides30S:Tetracyclines50S:Chloramphenicol50S:Macrolides,Lincosamides50S:Linezolide,Streptogramins Polymyxins Rifampicin AdverseDrugReactions(ADRs)Antibacterialdrugsmaycause:●directhosttoxicity(aminoglycosides,peptides)●toxicinteractionswithotherdrugs●...
One of the most commonly utilized groups of antimicrobial agents is the beta-lactam class of antibiotics. Although this class is comprised of a wide variety of agents, all beta-lactams share a similar structure, including a beta-lactam ring, which contributes to their mechanism of action (Beau...
Metallo-beta-lactamase: structure and mechanism. This past year has produced determinations of X-ray crystal structures for three metallo-beta-lactamases and the elucidation of the catalytic mechanisms fo... Z Wang,W Fast,AM Valentine,... - 《Current Opinion in Chemical Biology》 被引量: 610发...
127–129 A plethora of yet uncharacterized bioactive small molecules with privileged structures awaits elucidation of their cellular targets and mechanism of action.130 In this regard, the ABPP technology has made progress toward a systematic investigation of such natural product-derived molecular ...
The rapid spread of this mechanism of bacterial resistance can severely limit beta-lactam treatment options in the hospital and in the community. Currently available beta-lactamase inhibitors (for example, clavulanic acid and tazobactam) are poorly active against the diversity of beta-lactamase enzymes...