Bryan and Godfrey, ".beta.-Lactam Antibiotics: Mode of Action and Bacterial Resistance, Ch. 16" in Antibiotics in Laboratory Medicine, 3rd Ed., Lorian ed. pp. 599-663 (1991).Bryan, L. E., and A. J. Godfrey. 1991. Beta-lactam antibiotics: mode of action and bacterial resistance, p...
Its mode of action is similar to the bicyclic core of a cephalosporin (a representative bicyclic β-lactam substrate), and it may form hydrogen-bonding interactions with Asn233 and the water molecule W3. As a consequence of nonmetal binding and interaction features, compound 15...
The spectrum of action of clindamycin includes anaerobic bacteria and some Staphylococcus and Streptococcus strains. It is used to treat aspiration pneumonia and for patients with beta-lactam allergy. Doxycycline Doxycycline is a tetracycline antibiotic used to treat community acquired pneumonia (CAP) in...
Mode of inhibition of beta-lactamase I and penicillin binding proteins by a novel, synthetic, bifunctional, irreversible monocyclic beta-lactam. {dollar}beta{dollar}-Lactamase I was isolated from a constitutive penicillinase producing strain, Bacillus cereus 569/H. The mode of action of a novel, ...
in vivo. Our results provide structural insights into the mechanism of action and the inhibition of L,D-transpeptidation, and into YcbB-mediated antibiotic resistance. Similar content being viewed by others Structural basis of broad-spectrum β-lactam resistance inStaphylococcus aureus ...
The intra- cellular localisation of those bacteria provides them protection against the host immune system and action of antibiotics, leading to recurent infections1,2. In fact, some antibiotic families (i.e. β -lactams or aminoglycosides)3 fail to accumulate efficiently into eukaryotic cells ...
In general, the mode of action involves solubilization at the high pH within the target insect's gut, followed by proteolytic cleavage; the activated peptides form pores in the gut cell apical plasma membranes, causing lysis of the cells. The toxin has been genetically engineered into various ...
In general, the mode of action involves solubilization at the high pH within the target insect's gut, followed by proteolytic cleavage; the activated peptides form pores in the gut cell apical plasma membranes, causing lysis of the cells. The toxin has been genetically engineered into various ...
It will be understood, however, that the specific dose level and frequency of dosage for any particular patient may be varied and will depend upon a variety of factors including the activity of the specific compound employed, the metabolic stability and length of action of that compound, the ag...
WO2006017542A1 2006-02-16 SULFONYL COMPOUNDS AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 WO2006024627A2 2006-03-09 N-2 ADAMANTANYL-2-PHENOXY-ACETAMIDE DERIVATIVES AS 11-BETA HYDROXYSTEROID DEHYDROGENASE INHIBITORS WO2006024628A1 2006-03-09 TRICYCLIC LACTAM DERIVATIVES AS 11-BETA HYDROXYSTEROID...