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讲授内容 一、-内酰胺类抗生素的共性 二、细菌的耐药性三、青霉素类抗生素 四、头孢菌素类抗生素五、非典型-内酰胺类抗生素 第2页,共50页。β-内酰胺类抗生素(-Lactamantibiotics)系指化学结构中具有β-内酰胺环的一大类抗生素,临床最为常用的药物是:青霉素类:基本结构为6-氨基青霉烷酸 头孢菌素类:基本结构为...
beta-内酰胺类抗生素 -内酰胺类抗生素-lactamantibiotics 1 N A B C B-内酰胺环 2 -内酰胺类抗生素:青霉素类(penicillins)头孢菌素类(cephalosporins)非典型-内酰胺抗生素类 3 第一节-内酰胺类抗生素的共性 1.抗菌机制:抑制转肽酶活性触发细菌的细胞壁自溶酶活化 2.耐药机制...
beta内酰胺类抗生素.ppt 1、,-内酰胺类抗生素 (-lactam antibiotics),一、 -内酰胺类抗生素的共性二、细菌的耐药性三、青霉素类抗生素四、头孢菌素类抗生素五、非典型-内酰胺类抗生素,讲授内容,-内酰胺类抗生素(-Lactam antibiotics)系指化学结构中具有-内酰胺环的一大类抗生素,临床最为常用的药物是: 青霉素类:基本...
Antibacterially active and animal feedstuff supplement &bgr;- lactam antibiotics of the formula ##STR1## in which R is H or --UR',< P>< P>U is O or S,R' is optionally substituted alkyl, alkenyl, alkinyl, aralkyl, aryl or cycloalkyl,Z is ##STR2## R.sup.1 and R.sup.2 ...
Beta‐lactam Antibioticsantibiotic resistanceantimicrobial activitybeta‐lactam antibioticscephalosporinsdrug interactionsdoi:10.1002/9781118675014.ch10John F. PrescottJohn Wiley & Sons, Ltd
β-内酰胺类抗生素(-Lactamantibiotics)系指化学结构中具有β-内酰胺环的一大类抗生素,临床最为常用的药物是:青霉素类:基本结构为6-氨基青霉烷酸 头孢菌素类:基本结构为7-氨基头孢烷酸。一、-内酰胺类抗生素的共性 1.化学结构相似:青霉素类的基本结构为6-氨基青霉烷酸 6APA 头孢菌素的基本结构为7-...
BETA-LACTAMANTIBIOTICS(inhibitorsofcellwallsynthesis)Theirstructurecontainsabeta-lactamring.Themajorsubdivisionsare:(a)penicillinswhoseofficialnamesusuallyincludeorendin“cillin”(b)cephalosporinswhicharerecognizedbytheinclusionof“cef”or“ceph”intheirofficialnames.(c)carbapenems(e.g.meropenem,imipenem)(d)mono...
Beta-lactam antibiotics are a class of hydrophilic compounds with low volume of distribution that are mainly eliminated through the kidneys. They exhibit time-dependent bactericidal activity, with the percentage of time above the minimum inhibitory concentration (MIC) being the key factor for optimal ...
Thus, beta-lactam antibiotics in wide clinical use have marked effects on T-cell behavior; beta-lactam antibiotics can function as immunomodulators, apparently through covalent binding to albumin. 展开 关键词: HUMAN SERUM-ALBUMIN MULTIPLE-SCLEROSIS AUTOIMMUNE-DISEASE EPITHELIAL-CELLS NOD MOUSE PENICILLIN...