In summary, Hex {alpha} and Hex {beta} mRNAs are differentially and developmentally expressed at high levels in the rat testis and epididymis and augur for an important role for {beta}-hexosaminidase in normal male reproductive function. less 展开 ...
Sandhoff disease (SD) is a lysosomal storage disease, caused by loss of 尾-hexosaminidase (HEX) activity resulting in the accumulation of ganglioside GM2. There are shared features between SD and Parkinson's disease (PD). 伪-synuclein (aSYN) inclusions, the diagnostic hallmark sign of PD, ...
Beta-hexosaminidase activities in tears and plasma, diphosphoglycerate in blood of diabetic patients In a study on 10 normal controls, 7 pregnant women and 16 diabetic patients, β-hexosaminidase in tears and 2,3-diphosphoglycerate in blood were investigat... NJV Haeringen,JL Vrooland,E Glasiu...
The activity of beta-hexosaminidase (E C 3.2.1.30) in plasma and urine was determined in 99 patients with juvenile diabetes mellitus and in 40 age-matched controls. Plasma enzyme activities were above normal in plasma from diabetics and showed significant correlations with blood glucose and glycosy...
The lysosomal hydrolase beta-hexosaminidase (beta-N-acetylhexosaminidase, EC 3.2.1.52) exists as two major isozymes in normal human tissue: an acidic A-form and a basic B-form. There are also minor forms of intermediate pI known as I-forms. Increases in one or more of these intermediates ...
Life SciencesResveratrol efficiently improves pulmonary function via stabilizing mast cells in a rat intestinal injury modelpubmed:28733146 Neural Regen ResFunctionality of a bicistronic construction containing HEXA and HEXB genes encoding ¦Â-hexosaminidase A for cell-mediated therapy of GM2 gangliosi...
Critical roles of lysosomal enzyme activity assay, which showed elevated α-iduronidase, iduronate sulfatase, galactose-6-sulphate sulphatase, arylsulfatase B and α-hexosaminidase activities; and genetic study, which confirmed the parental origin of both mutations, were highlighted....
Parsons T. B., et al., (2010) Streptococcus pneumoniae endohexosaminidase D: feasibility of using N-glycan oxazoline donors for synthetic glycosylation of a GlcNAc-asparagine acceptor. Org. Biomol. Chem. 8, 1861-1869. Raju T. S., et al., (2006) Glycosylation in the Fc domain of IgG in...
We examine the function of the pro beta-peptide (residues 42-121) in the folding and intracellular transport of human beta-hexosaminidase B (beta-N-acetylhexosaminidase, EC 3.2.1.52). A construct was prepared that encoded an in frame deletion of residues 55-118. Expression of this construct ...
renal functionstrokeurineUrinary -hexosaminidase is a sensitive indicator of renal damage. The urinary excretion of this enzyme was measured in 31 patients with ischaemic stroke in the acute phase and in 126 patients 2143 weeks after their stroke. Both immediately and after 2143 weeks the patients ...