Structures of the homodimeric native structure and its complex with the substrate analog 2-methylaspartate have been refined, respectively, with 1.74-A x-ray diffraction data to an R...doi:10.1016/B978-0-08-040820-0.50041-8C.M. METZLER...
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In parallel, H3.3K27M had no effect on classic kinase-related proliferation pathways, including the AKT, MEK1/2 and STAT3 pathways. As the glioblastoma microenvironment is multifaceted and is composed of soluble factors, extracellular matrix components and tissue-resident cell types along with ...
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Collectively, these data suggest that the prolonged inhibition of the MEK1/2-ERK signaling axis reverses tolerance and primed macrophages likely through decreasing the H3K9 methylation levels.Low, RachelHa, Soon-DuckSleapnicov, NichitaManeesh, Parthiv...
Spectrum of hepatocyte nuclear factor 1beta mutations in a prospective cohort of patients with congenital renal abnormalitiesMekahli, DjalilaVan Ackere, TCorveleyn, AVan Dyck, MVan Hoyweghen, ElkeKnops, NLombaertsVan Damme, RDevriendt, Koenraad...