These mediators, such as histamine, elicit vasodilation, increased vascular permeability, oedema and acute functional changes in affected organs. The IgE-mediated early phase reaction occurs within minutes of allergen exposure. It can be either localized with symptoms such as rhinitis, conjunctivitis, ...
The functions of this co-repressor complex rely on expression of p65 and the methyltransferase activity of EZH2 for ERβ to elicit anti-cancer effects. These results describe new biology of ERβ in TNBC and further our understanding of its mechanisms of action in this sub-type of the disease...
ERβ elicites tumor-suppressive effects, particularly with regard to suppression of metastatic phenotypes, which is characterized by the induction of a family of secreted proteins known as cystatins and the subsequent inhibition of canonical transforming growth factor (TGF-β) signaling [89], leading ...
Generated Excel files automatically suppress that class of error, but other formats may elicit errors.Type z represents blank stub cells. They are generated in cases where cells have no assigned value but hold comments or other metadata. They are ignored by the core library data processing ...
et al. Failure of glucose to elicit a normal secretory response in fetal pancreatic beta cells results from glucose insensitivity of the ATP-regulated K+ channels. Proc. Natl Acad. Sci. USA 86, 4505–4509 (1989). Article CAS ADS PubMed Google Scholar Blum, B. et al. Functional beta-...
Here, we developed a novel long-acting IL-2 mutein, HM16390, that preferentially binds to IL-2R beta and an optimal binding property to alpha subunit to elicit a potent anti-tumor activity with improved safety. Methods Pharmacokinetics of HM16390 were evaluated in mice after single subcutaneous...
This is because low delays tend to elicit little discounting and there is an upper bound on indifference points at 1. Similarly, for very large delays, individuals tend to have indifference points near the boundary of 0 where there is little “wiggle room” and thus lower variance. By ...
In addition to classical canonical WNT-induced activation of β-catenin–TCF/Lef1 transcriptional complexes, WNT can elicit alternative responses through β-catenin independent mechanisms which are collectively known as noncanonical pathways [19]. In an alternative concept known as integrated Wnt pathway,...
To elicit societal and patient utilities associated with diabetic symptomatic non-severe hypoglycaemia for three health states: 1) rare (quarterly), 2) int... AR Levy,TL Christensen,JA Johnson - 《Health Qual Life Outcomes》 被引量: 166发表: 2008年 Mechanisms of glucagon secretion during insulin...
In contrast, TGF-beta was found to elicit the formation of tube-like structures (mimicking angiogenesis) when microvascular endothelial cells were grown in three-dimensional collagen gels. In this culture system TGF-beta elicited rapid extensive formation of complex, branching, tube-like structures, ...