Cell Differentiation UnitBentham Science PublishersCurrent Diabetes ReviewsBouwens L. Beta cell regeneration. Curr Diabetes Rev 2006;2:3–9.Bouwens L. Beta cell regeneration. Curr.Diabetes Rev 2006;2:3-9. [PubMed: 18220612]Bouwens L (2006) Beta cell regeneration. Curr Diabetes Rev 2:3–9...
the research team reports that the new, regenerated beta cells may be coming from an unexpected source: a second pancreatic cell type called alpha cells. Since alpha cells are abundant in people with type 1 and type 2 diabetes, they may be able to serve as a source for new beta ...
inducing human beta cells to regenerate is difficult. Reasoning that insulinomas hold the “genomic recipe” for beta cell expansion, we surveyed 38 human insulinomas to obtain insights into therapeutic pathways for beta cell regeneration. An integrative analysis of whole-exome and RNA-sequencing data...
Key Words: Diabetes therapies; Beta cell regeneration; Regenerative medicine; Stem cell therapy; Gene editing; Molecular therapeutics Core Tip: Diabetes, a disease of uncontrolled blood sugar, arises from the loss or dysfunction of insulin-producing beta cells within the pancreas. While traditional ...
1. Dor Y, Brown J, Martinez OI and Melton DA. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature. 2004;429:41-46. 2. Solar M, Cardalda C, Houbracken I, Martin M, Maestro MA, De Medts N, Xu X, Grau V, Heimberg H, Bouwens ...
beta cell regenerationBackgroundOver the past decade, many immune tolerance agents have shown promise in the non-obese diabetic mouse model for prevention and reversal of type 1 diabetes but have not been successful in clinical trials among recently diagnosed type 1 patients. The trials from ...
Several groups have identified the Regeneration gene family (Reg) as being expressed during the process of WIN and β-cell regeneration in the pancreas [3, 5, 7, 9, 12]. There are seven types of Reg genes present in the mouse (located on chromosome six with the exception of Reg 4) bu...
Keywords: islet progenitor cells, pro-α-cells, de-di erentiation, trans-di erentiation, β-cell regeneration Abbreviations: GLP-1, glucagon-like peptide-1; SDF-1, stromal cell-derived actor-1; PC, prohormone convertase Historically, the α-cells were discovered by virtue o the iden- ...
beta cell regeneration is unknown. In a new study in mice, Helmholtz Zentrum München in collaboration with Novo Nordisk, demonstrated for the first time that a targeted combinatorial drug treatment is able to restore beta cell function, achieve beta cell redifferentiation and therefore potentially ...
Cell Stem Cell | 周斌/何奔合作建立谱系示踪新技术发现成体脂肪干细胞; Dev Cell | 周斌研究组利用谱系示踪技术无缝隙捕捉体内肿瘤转移中的EMT过程 制版人:十一 参考文献 1. Dor Y, Brown J, Martinez OI and Melton DA. Adult pancreat...