H Kaneto,Y Nakatani,D Kawamori,T Miyatsuka,TA Matsuoka,M Matsuhisa,Y Yamasaki.Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance. International Journal of Biochemistry Cell Biology The . 2006...
This review will focus on the importance of insulin resistance and beta-cell dysfunction in the pathogenesis of Type 2 diabetes. In the course of the discussion, it will be apparent that changes in beta-cell function are both an early and critical component in the pathogenesis of the hyperglyca...
C. et al. Peripheral insulin resistance rather than beta cell dysfunction accounts for geographical differences in impaired fasting blood glucose among sub-Saharan African individuals: Findings from the RODAM study. Diabetologia 60, 854–864. https://doi.org/10.1007/s00125-017-4216-4 (2017). ...
Kahn: The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology sistance [2, 3]. In contrast, others have suggested that reduced beta-cell function, manifest as decreased in- sulin release, is a prerequisite for the progression from NGT to hyperglycaemia [4...
Beta cell loss and insulin resistance play roles in the pathogenesis of type 2 diabetes. Elevated levels of free fatty acids in plasma might contribute to the loss of beta cells. The objective of this study was to find a chemical that could protect against palmitate-induced beta cell death an...
Importantly, glutamine deprivation significantly exacerbated these phenotypes, suggesting that low glutamine levels could participate in the process of beta cell dysfunction in T2D. Introduction Maintenance of glucose homeostasis requires metabolic and insulin secretory adaptations by pancreatic beta cells in ...
“An ideal diet for type 2 diabetes would address the key pathophysiologic mechanisms behind the disease, which is the insulin resistance and beta-cell dysfunction,”Hana Kahleova, MD, PhD,director of clinical research with the Physicians Committee for...
Beta cell dysfunction and insulin resistance. Front. Endocrinol. 2013, 4, 37. [Google Scholar] [CrossRef] Linnemann, A.K.; Baan, M.; Davis, D.B. Pancreatic β-cell proliferation in obesity. Adv. Nutr. 2014, 5, 278–288. [Google Scholar] [CrossRef] Butler, A.E.; Janson, J.; ...
Type 2 diabetes, characterized by persistent hyperglycemia, arises mostly from beta cell dysfunction and insulin resistance and remains a highly complex metabolic disease due to various stages in its pathogenesis. Glucose homeostasis is primarily regulated by insulin secretion from the beta cells in respo...
Long-term exposure to hyperglycemic conditions leads to β-cell dysfunction, particularly mitochondrial dysfunction, and inflammatory and oxidative stress responses, which are considered the primary causes of β-cell death and the hallmarks of diabetes.