Cell Meter Beta-Arrestin Translocation GPCR Signaling Kit 一、化学性质与结构 Cell Meter Beta-Arrestin蛋白易位GPCR信号检测试剂盒是一套基于β-Arrestin蛋白易位机制，结合荧光标记检测的细胞信号转导分析系统。其核心组成包括：荧光标记的β-Arrestin融合蛋白表达质粒 GPCR激动剂/拮抗剂处理体系 荧光成像试剂和缓冲液 ...
β-arrestin(一种细胞质蛋白)与激活的受体的结合使GPCR信号失活,并启动了受体向细胞内的易位,在此细胞中配体被去除,受体被循环回到细胞膜。通过将荧光标记(例如GFP)附着到β-arrestin,可以检测受体arrestin复合物的位置。由于脱敏仅发生在激活的受体上,因此检测β-arrestin的易位和随后的受体再循环提供了检测GPCR靶标...
β-arrestin(一种细胞质蛋白)与激活的受体的结合使GPCR信号失活,并启动了受体向细胞内的易位,在此细胞中配体被去除,受体被循环回到细胞膜。通过将荧光标记(例如GFP)附着到β-arrestin,可以检测受体arrestin复合物的位置。由于脱敏仅发生在激活的受体上,因此检测β-arrestin的易位和随后的受体再循环提供了检测GPCR靶标...
品名:PathHunter eXpress MC4R U2OS Beta-Arrestin GPCR Assay 规格:1,000 dp (10 x 96-well) 货号:93-0211E3CP0L 一、我们关于PathHunter eXpress MC4R U2OS Beta-Arrestin GPCR Assay蛋白、试剂盒、补体的声明 我们致力于成为科研试剂搜索、采购一体化解决方案提供商!
[beta]-arrestins regulate G protein-coupled receptor (GPCR) desensitization and/or act as scaffolds for assembly of downstream signaling complexes. CaR regulates cell proliferation, differentiation and/or apoptosis via activation of mitogen-activated protein kinase (MAPK) cascades via a pathway which ...
Beta-arrestins function in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the ...
Beta-arrestin is a multifunctional adapter protein well known for its role in G-protein-coupled receptor (GPCR) desensitization. Exciting new evidence indicates that β-arrestin is also a signaling molecule capable of initiating its own G-protein-independent signaling at GPCRs. One of the best-...
Beta Arrestin 2 is a member of arrestin/beta-arrestin protein family, which are expressed at high levels in the central nervous system (CNS) and play a critical role in the regulation of G-protein coupled receptors (GPCRs) including MOR. Beta Arrestin 2 is an adaptor protein that is import...
作为一个衔接或支架分子,β-抑制蛋白1是有丝分裂信号的必要条件。介导G蛋白偶联受体(gpcrs,例如β2肾上腺素能受体)的激动剂依赖性脱敏和内化。在与配体结合并与异源三聚体G蛋白相互作用后,gpcrs被丝氨酸残基上的G蛋白受体激酶(GRK)磷酸化。β-抑制蛋白1在细胞质和β-抑制蛋白1/2抗体(Beta-arrestin 1)...
B-arr2 招募细胞测定通过 GPCR 激活监测 B-arrestin 2 和 AP2 的招募。B-arr2 招募试剂盒用于通过监测内源性 B-arrestin 2 与其伴侣 AP-2 之间的相互作用来表征化合物对 Beta 抑制蛋白信号通路的影响。 从文献中得知,在研究 GPCR 背景下的 Beta 抑制蛋白信号通路时,对这种相互作用的药理学研究是相关的。