Presents a study to determine whether functional beta-adrenergic receptors (BAR) are present on proximal tubule epithelial cells (PTEC) of rat kidney. Proximal tubule cell isolation and maintenance; Hormone incubations and cAMP assay; Apical and basolateral BAR binding constants; Effects of various ...
Beta-adrenergic receptor function in rat proximal tubule epithelial cells in culture. Presents a study to determine whether functional beta-adrenergic receptors (BAR) are present on proximal tubule epithelial cells (PTEC) of rat kidney. Prox... Hanson,Alan,S.,... - 《American Journal of ...
Structure and function of the beta 3-adrenergic receptor. The beta 3 subtype of adrenaline and noradrenaline receptors has now been extensively characterized at the structural and functional levels. Ligand binding... AD Strosberg - 《Advances in Pharmacology》 被引量: 518发表: 1998年 Structural basi...
Homologous or agonist-specific desensitization of β-adrenergic receptors is thought to be mediated by a specific kinase, the β-adrenergic receptor kinase (βARK). However, recent data suggest that a cofactor is required for this kinase to inhibit receptor function. The complementary DNA for such...
Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase. Three separate processes may contribute to rapid beta-adrenergic receptor desensitization: functional uncoupling from the stimulatory guanine nucleotide-bi... ...
Twitter Google Share on Facebook (redirected frombeta-adrenergic receptors) Thesaurus Medical Financial Encyclopedia be·ta (bā′tə, bē′-) n. 1.The second letter of the Greek alphabet. See Table atalphabet. 2.The second item in a series or system of classification. ...
Structure-function of alpha1-adrenergic receptors The Easson-Stedman hypothesis provided the rationale for the first studies of drug design for the alpha(1)-adrenergic receptor. Through chemical modificati... DM Perez - 《Biochemical Pharmacology》 被引量: 61发表: 2007年 II. Beta-adrenergic recepto...
Turning off the signal: desensitization of beta-adrenergic receptor function. Cellular responses to many hormones and neurotransmitters wane rapidly despite continuous exposure of cells to these stimuli. This phenomenon, termed desen... WP Hausdorff,MG Caron,RJ Lefkowitz - 《Faseb Journal》 被引量: ...
Altered expression and functional responses to cardiac beta(3)-adrenergic receptors (ARs) may contribute to progressive cardiac dysfunction in heart failure (CHF). We compared myocyte beta(3)-AR mRNA and protein levels and myocyte contractile, [Ca(2+)](i) transient, and Ca(2+) current (I(...
β-Adrenergic Function in Aging Drugs & Aging 1: pp. 116-129Scarpace PJ,Tumer N,Mader SI,et al.Beta-adrenergic function in aging.Basic mechanisms and clinical implications. Drugs and Aging . 1991Scarpace, P.J., Tumer, N., Mader, S.L., 1991. Beta-... DPJ Scarpace,N Turner,SL ...