These interactions play a crucial role in the encapsulation process, where citric acid is captured within the hydrophobic cavity of beta-cyclodextrin. The key forces driving this complexation are two-fold. Beta-cyclodextrin has a hydrophobic interior cavity, which can accommodate hydrophobic guest ...
ATP7The Drosophila Slimb (Slmb) gene encodes a Skpl-Cull-F-box (SCP) E3 ubiquitin ligase orthologous to the human beta-TrCP/BTRC protein. Slmb and/or BTRC play regulatory roles in numerous biological processes by ubiquitinating several substrate proteins which are then targeted for proteasomal ...
These soluble Aβaggregates are believed to be play a critical role in neurodegeneration relating to Scientific Reports | 6:38187 | DOI: 10.1038/srep38187 8 www.nature.com/scientificreports/ dementia of the Alzheimer's type, however they had not been previously isolated from human brain ...
efficient clearance of senescent cells to promote healthspan during normal aging (Baar et al., 2017, Baker et al., 2016, Chang et al., 2016, Kirkland and Tchkonia, 2017), our work illustrates that senescence and SASP can play a major role in the pathology of a disease not related to ...
More recently, HSCP70 (heat shock cognate protein 70) has been identified a potential receptor or co-receptor, and has been shown to interact with grouper NNV capsid and plays a crucial rule in the early stages of infection [132]. 5. Host-pathogen interactions 5.1. The pathogen response ...
H OH metabolites OH Article Thyroid Hormone Receptor Isoforms Alpha and Beta Play Convergent Roles in Muscle Physiology and Metabolic Regulation Annarita Nappi 1 , Melania Murolo 1, Annunziata Gaetana Cicatiello 1, Serena Sagliocchi 1, Emery Di Cicco 1, Maddalena Raia 2, Mariano Stornaiuolo 3...
two of which, α- and β-synuclein, play a major role in the development of synucleinopathies, including Parkinson's disease (PD) as most important movement disorder, dementia with Lewy bodies (DLB) as the second most frequent cause of dementia after Alzheimer's disease and multiple system ...
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However, the Aβ(25–35) fragment, which is physiologically predominant in aged individuals, has just been revealed to play a key role in AD due to its particular aggregation characteristics [14,15]. Furthermore, it was noticed that there is a clear connection between the development of ...
FAP is a dimeric protease localized primarily on the cell surfaces of cancer-associated fibroblasts (CAFs), which have been shown to play a protumoral role [8]. Generally, CAFs are known to increase tumor cell invasion, angiogenesis and tumor growth and their presence correlates with a poor ...