β2-glycoprotein I (β2-GPI), also known asapolipoproteinH, is one of theautoantigensappearing to be important factors for promoting atherosclerotic lesions. β2-GPI is a circulatingglycoproteinthat was first described in 1961. Since its recognition, the major contributions for the elucidation o...
Anti-domain 1 of beta2-glycoprotein IAntiphospholipid antibodiesLupus anticoagulant (LA) is considered a risk factor for thromboembolism (TE) and adverse pregnancy outcomes (APOs). However, quite a few patients diagnosed with LA positivity do not suffer these adverse events. Further testing of anti...
Now, antibody is defined as a glycoprotein induced by antigenic challenge regardless of the in vitro or in vivo function of that molecule (reviewed in Lindenmann, 1976). Today the terms antibody and immunoglobulin are often used interchangeably. Between the 1930s and 1966 several different classes...
Isolated elevation of IgA anti-beta2- glycoprotein 1 antibodies with manifestations of antiphospholipid syndrome : A case series of five patients. Lupus 2009;18:1011-4.Kumar S,Papalardo E,Sunkureddi P, et al. Isolated elevation of lgA anti-beta2glycoprotein I antibodies with manifestations of ...
Within the subgroup of patients with significant coronary artery stenosis, anti-CL antibodies were also elevated (p = 0.008). No correlation was found between anti-CL, and anti-β[sub 2] GPI autoantibody levels and coronary calcium scores as measured by spiral computerized tomography. However, ...
It is interesting to note that, although 2006 Sydney antiphospholipid syndrome classification criteria has included IgG/IgM anti-cardiolipin, IgG/IgM anti-β2-glycoprotein antibodies and lupus anticoagulant, some patients suffering from antiphospholid syndrome still remain sero-negative (sero-negative APS...
To identify proteins that display low or no expression in low-grade astrocytoma but elevated levels in GBM, glycoprotein fibronectin (FN) was particularly examined according to the mining of the Human Protein Atlas. Web- based open megadata minings revealed that FN was mainly mutated in the ...
prediction of AD risk also demonstrated the association between integrin β3 and β-gal and AD phenotypes. Moreover, we showed that elevated integrin β3 levels were accompanied by senescence phenotypes and immune cell accumulation in AD mouse colonic tissue. Further, integrin β3 genetic ...
Reactive Microglia in Patients with Senile Dementia of the Alzheimer Type Are Positive for the Histocompatibility Glycoprotein HLA-DR. Neurosci. Lett. 1987, 79, 195–200. [Google Scholar] [CrossRef] [PubMed] Salminen, A.; Kaarniranta, K.; Kauppinen, A. Inflammaging: Disturbed Interplay ...
Chondroitin sulfate (CS) is a major component of the extracellular matrix found to be abnormally accumulated in several types of cancer tissues. Previous studies have indicated that CS synthases and modification enzymes are frequently elevated in human gliomas and are associated with poor prognosis. Ho...