APP is a membrane-spanning glycoprotein, which is present at the plasma membrane, endoplasmic reticulum (ER), trans-Golgi network (TGN) and endocytic vesicles (Canevari et al., 2004). APP processing is complex where three different enzymes rapidly metabolize it producing either toxic or non-...
The amyloid precursor protein (APP) is a type I transmembrane glycoprotein that undergoes proteolytic processing along two major pathways: the amyloidogenic and the non-amyloidogenic pathway1. In the amyloidogenic pathway, two enzymes (β- and γ-secretase) cleave APP into several Aβ peptide vari...
Therefore, a plausible hypothesis is that through the modulation of microglial functions, TREM2 contributes to the reduction in Aβ deposition and consequent loss of synapsis that is observed in AD mouse models [67]. The interpretation that upregulation of TREM2 acts as a compensatory response to...
In historical terms, recognition of an agent as a herpesvirus has rested on morphology: a linear, double-stranded DNA genome packed into a T = 16 icosahedral capsid, embedded in a complex protein layer known as the tegument, wrapped in a glycoprotein-containing lipid membrane, yielding a spheri...
The vast majority of SARS-CoV-2 vaccines are based on the spike (S) glycoprotein, a homotrimeric glycoprotein that plays a pivotal role in viral entry and consists of an S1 subunit including the receptor binding domain (RBD) and an S2 subunit containing the fusion peptide28, 29. The RBD ...
Defects in the low density lipoprotein receptor-related protein-1 (LRP-1) and p-glycoprotein (Pgp) clearance of amyloid beta (Aβ) from brain are thought to contribute to Alzheimer’s disease (AD). We have recently shown that induction of systemic inflammation by lipopolysaccharide (LPS) result...
Protein levels of OSTα and OSTβ were higher than P-glycoprotein (P-gp/MDR1/ABCB1). New antibodies have been produced as part of the Human Protein Atlas project (Uhlen et al., 2015), which confirmed, using microarray-based immunohistochemistry, the protein expression of OSTα and OSTβ ...
However, diabetes development is dramatically differently affected, depending on whether the viral protein is a surface antigen (glycoprotein, GP) or a nuclear antigen (nucleoprotein, NP). Mice expressing IL-6 and nuclear protein (NP) in the β-cells became spontaneously diabetic. In contrast, ...
Like IL-17A and IL-17F, IL-22 is a glycoprotein, which binds to its receptor complex (composed of IL-10Rβ and IL-22Rα) as a homodimer [17, 18]. The IL-22 receptor complex is highly expressed in the pancreatic α and β cells [19]. Upon receptor binding, the tyrosine kinases,...
8.The method of claim 1, wherein the step of providing a fucosylated or nonfucosylated GLcNAc acceptor protein comprises(a) providing a fucosylated or nonfucosylated glycoprotein substrate comprising at least two GlcNAc residues having a covalent bond between the at least two GlcNAc residues, wherei...