However, in type 1 diabetes or the late stage of type 2 diabetes characterized by poor β-cell function, berberine was able to increase insulin secretion via repairing destructed or exhausted islets, which may be related to its antioxidant and anti-lipid peroxidation properties15. 5. Berberine ...
Although berberine (BBR) has shown promising effect in the treating diabetes and cognitive dysfunction, more research is needed to understand the mechanism of its therapeutic effect. For better understanding, we investigated the functions of BBR involved in anti-inflammation, anti-oxidant and ...
Akkermansia muciniphila is a representative gut microbe favoring for host immunity and metabolism [2], [3], which can strengthen intestinal barrier by promoting mucus secretion [4]. Pharmacological studies revealed that the therapeutic effect of metformin on diabetes is partly mediated by promotion ...
Diabetes. 2006;55:2256–64. CrossRef Turner N, Li JY, Gosby A, To SW, Cheng Z, Miyoshi H, et al. Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated ...
Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism 2010; 59: 285–292. 5 Rayasam GV, Tulasi VK, Sundaram S, Singh W, Kant R, Davis JA et al. Identification of berberine as a novel agonist of fatty acid receptor GPR...
For example, BBR was found to activate AMP-activated protein kinase (AMPK), which has beneficial effects on metabolically disordered states of diabetes7. The effects of BBR of inducing apoptosis and inhibiting cancer cell migration and metastasis are also associated with AMPK activation8–10. ...
Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 55: 2256-2264, Jeong, H. W., Hsu, K. C., Lee, J. W., Ham, M., Huh, J. Y., Shin, H. J., Kim, W. S., Kim. J. B...
diabetesinteractionα-amylaseα-glucosidaseBerberine is separated from medical plants and food raw materials, and shows excellent anti‐diabetic activity and could be used as a food additive in some countries and regions. However, its inhibitory mechanisms on α‐amylase and α‐glucosidase have hardly...
Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control Diabetes Metab. Syndr. Obes., 5 (2012), pp. 213-217 View in ScopusGoogle Scholar Downward, 1998 J. Downward Mechanisms and consequences of activation of protein Kinase...
BBR has a broad spectrum of pharmacological effects with extremely low bioavailability and has been shown to be clinically effective in treating metabolic disorders by regulating gut microbiota, such as hyperlipidaemia and diabetes mellitus (Kong et al., 2020, Xu et al., 2021). However, there is...