Both direct and non‐competitive two‐site (sandwich) immunoassays are reported for 3‐phenoxybenzoic acid (3‐PBA) utilizing signal transduction by electrochemical impedance spectroscopy (EIS), and the sandwich immunoassay reduces the detection limit for this small molecule analyte by ~70×. The ...
The carboxylic acid interacted with the catalytic lysine (K68), while one of the pyrazine nitrogens formed the main H-bond with the hinge region (Fig. 3A). The three rings of 6c adopted a co-planar conformation as is commonly seen in other CSNK2A inhibitors. The aniline 7c (PDB: 8...
Examples of pharmaceutically-acceptable antioxidants include: (1) water soluble antioxidants, such as ascorbic acid, cysteine hydrochloride, sodium bisulfate, sodium metabisulfite, sodium sulfite and the like; (2) oil-soluble antioxidants, such as ascorbyl palmitate, butylated hydroxyanisole (BHA), butylat...
Polo-like kinase inhibitor, antitumor agent, antiproliferative agent for treating breast, colon, lung and prostate tumors; 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxy-benzoic acid; ch ...
The growth factor-like lysophospholipids lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) regulate many fundamental cellular responses, including cell survival, cell proliferation, cellular motility and migration. LPA has been shown to have profound activity in preventing apoptosis and rescuing...
4-(1H-imidazol-1-yl) benzoic acid and its coordination polymers [M(IBA)Cl] n (M=Zn (1) and Co (2)) have been synthesized. Compounds 1 and 2 were obtained under ionothermal conditions and possess a 2-D laminar [M(IBA)] n layer based on M2(CO2)2 building blocks with coordinated ...
hupehensis Rehd seedlings were treated with phloridzin, phloretin or benzoic acid, respectively. The identified protein spots could be classified into 8 functional groups as follows: signal transduction-related proteins, pathogenesis-related proteins, metabolism-related proteins, free radical scavenging ...
Impedance Detection of 3‐Phenoxybenzoic Acid with a Noncompetitive Two‐site Phage Anti‐immunocomplex Assay The cover picture shows formation of a ternary complex between M13 bacteriophage, 3‐phenoxybenzoic acid (3‐PBA), and the polyclonal antibody to 3‐PBA. This use of bacteriophage ...
The construction of rigid spacers composed of amino propynyl benzoic acid building blocks is described. These spacers were used to link two phosphopeptide ligand sites towards obtaining divalent ligands with a high affinity for Syk tandem SH2 domains, which are important in signal transduction. The...