The specific binding was enhanced by the GABA-A agonist, muscimol. In both rats and cats, neither acute nor chronic administration of benzodiazepines or their antagonists altered the retinal functions, as determined by the electroretinogram. These results suggest that retinal benzodiazepine receptors ...
The effects of several benzodiazepines on a variety of nervous activities known or presumed to depend on GABA are presented and compared with those of agen... W Haefely,A Kulcsár,H Möhler,... - 《Psychopharmacology Bulletin》 被引量: 503发表: 1975年 Rebound insomnia. A potential hazard fo...
Benzodiazepine antagonistFlumazenilThe hypothesis that agonist ligands of the central benzodiazepine (BZ) receptor contribute to the manifestations of hepatic encephalopathy (HE) by enhancing the action of GABA was originally suggested by anecdotal observations of ameliorations of HE following administration ...
Choose a medication that acts as either an agonist or antagonist. Name of medication, the receptor that it binds to, and what kind of reaction it causes. Give an example of a patient that would be taking this medication. Which drugs ...
The effects of zopiclone (0.1-100 mg/kg) were studied alone and in combination with the benzodiazepine receptor antagonist Ro 15-1788 and the inverse agonist ethyl-beta-carboline-3-carboxylate (beta-CCE). Under one procedure, food-mainta... JE Barrett,LS Brady,JA Stanley,... - 《Journal ...
an antileukotriene (or steroid) in asthma therapy. Indicate the antiseizure drug - a benzodiazepine receptor agonist: a. Phenobarbital b. Phenytoin c. Carbamazepine d. Lorazepam Similar to alcohol, this drug stimulates the release of GABA int...
Moreover, the benzodiazepine antagonist flumazenil did not alter the enhancement of GABA response by curcumol and menthol, but abolished that by DZP. Finally, mutations at the β2 or γ2 subunit predominantly eliminated modulation of recombinant GABAARs by curcumol and menthol, or diazepam, ...
A comparison of the effects of a subtype selective and non-selective benzodiazepine receptor agonist in two CO2 models of experimental human anxiety Studies in human volunteers that can demonstrate proof of concept are attractive in that possible mechanisms and potential new drug treatments can be exam...
BDZs such as diazepam or clonazepam increased tonic and clonic components of PDC. These effects were not antagonized by Ro 15-1788, a benzodiazepine receptor antagonist. The increased tonic component was antagonized by the GABA receptor antagonists, bicuculline and picrotoxin, whereas the clonic ...
The concentration-EEG effect relationships of the benzodiazepine agonist midazolam, partial agonist bretazenil, antagonist flumazenil and inverse agonist Ro 194603 were quantified and compared with the intrinsic efficacy and affinity of these compounds at the -aminobutyric acid (GABA)-benzodiazepine receptor...