New enantiomerically pure 1,2-dihydropyridine and its use for construction of optically active 2-azabicyclo[2.2.2]octane That is, the presence of AlCl3 efficiently promoted the Diels–Alder reaction to give a cycloadduct with high stereoselectivity, which was converted to an... MO Onomura - 《...
Reagents and conditions: (a) AlCl3, CH2Cl2; (b) Br2, CH2Cl2; (c) HCl; and (d) CH2Cl2. In the first step, the corresponding aromatic ketone was obtained in the Friedel–Crafts reaction. NextI,nththeebfrirosmt sinteapti,otnheocfotrhreesopbotnadininedg aarroommaattiicckkeettoonneewwaist...